Nutritional and metabolic effects of the endotoxin bacterial lipopolysaccharide in orally and parenterally fed rats
Animals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy by total parenteral nutrition (TPN). We sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats. Rat...
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Published in | The American journal of clinical nutrition Vol. 71; no. 3; pp. 835 - 843 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Bethesda, MD
American Society for Clinical Nutrition
01.03.2000
American Society for Clinical Nutrition, Inc |
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Abstract | Animals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy by total parenteral nutrition (TPN).
We sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats.
Rats were randomly allocated to 5 groups: oral nutrition (ON control; n = 7), TPN control (n = 7), ON+LPS (n = 6), TPN+LPS (n = 9), and pair fed (PF) in relation to ON+LPS (n = 6).
Body weight decreased significantly as diet consumption decreased in the ON+LPS and PF groups compared with the ON control group. Relative carcass weights were significantly lower in the TPN+LPS and ON+LPS groups than in their respective control groups. Diaphragm and extensor digitorum longus weights were significantly lower in the ON+LPS and PF rats, but not in the TPN+LPS rats, compared with their respective controls. Biochemical abnormalities and plasma corticosterone concentrations were greater in the TPN+LPS group than in the other groups.
These data suggest that provision of sufficient protein and energy by TPN does not prevent general carcass wasting induced by LPS but may protect individual muscles. However, compared with an oral ad libitum diet, TPN providing sufficient protein and energy worsens the biochemical abnormalities induced by LPS. More rapid clearance of TNF-alpha and low corticosterone concentrations in weight-losing animals may help reduce the severity of the metabolic effects of LPS. |
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AbstractList | BACKGROUNDAnimals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy by total parenteral nutrition (TPN).OBJECTIVEWe sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats.DESIGNRats were randomly allocated to 5 groups: oral nutrition (ON control; n = 7), TPN control (n = 7), ON+LPS (n = 6), TPN+LPS (n = 9), and pair fed (PF) in relation to ON+LPS (n = 6).RESULTSBody weight decreased significantly as diet consumption decreased in the ON+LPS and PF groups compared with the ON control group. Relative carcass weights were significantly lower in the TPN+LPS and ON+LPS groups than in their respective control groups. Diaphragm and extensor digitorum longus weights were significantly lower in the ON+LPS and PF rats, but not in the TPN+LPS rats, compared with their respective controls. Biochemical abnormalities and plasma corticosterone concentrations were greater in the TPN+LPS group than in the other groups.CONCLUSIONSThese data suggest that provision of sufficient protein and energy by TPN does not prevent general carcass wasting induced by LPS but may protect individual muscles. However, compared with an oral ad libitum diet, TPN providing sufficient protein and energy worsens the biochemical abnormalities induced by LPS. More rapid clearance of TNF-alpha and low corticosterone concentrations in weight-losing animals may help reduce the severity of the metabolic effects of LPS. Animals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy by total parenteral nutrition (TPN). We sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats. Rats were randomly allocated to 5 groups: oral nutrition (ON control; n = 7), TPN control (n = 7), ON+LPS (n = 6), TPN+LPS (n = 9), and pair fed (PF) in relation to ON+LPS (n = 6). Body weight decreased significantly as diet consumption decreased in the ON+LPS and PF groups compared with the ON control group. Relative carcass weights were significantly lower in the TPN+LPS and ON+LPS groups than in their respective control groups. Diaphragm and extensor digitorum longus weights were significantly lower in the ON+LPS and PF rats, but not in the TPN+LPS rats, compared with their respective controls. Biochemical abnormalities and plasma corticosterone concentrations were greater in the TPN+LPS group than in the other groups. These data suggest that provision of sufficient protein and energy by TPN does not prevent general carcass wasting induced by LPS but may protect individual muscles. However, compared with an oral ad libitum diet, TPN providing sufficient protein and energy worsens the biochemical abnormalities induced by LPS. More rapid clearance of TNF-alpha and low corticosterone concentrations in weight-losing animals may help reduce the severity of the metabolic effects of LPS. We sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats. |
Author | MATSUI, J RAINA, N JEEJEEBHOY, K. N |
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Cites_doi | 10.1042/bj1460141 10.1083/jcb.107.4.1269 10.1177/014860719702100107 10.1016/0166-6851(80)90046-8 10.1093/ajcn/68.6.1284 10.1177/0148607195019005341 10.1016/0006-8993(91)90154-N 10.4049/jimmunol.139.12.4122 10.4049/jimmunol.135.6.3972 10.1126/science.3895437 10.1111/j.1476-5381.1993.tb13893.x 10.1016/S0171-2985(86)80064-X 10.1056/NEJM198702123160705 10.1016/0016-5085(93)90857-9 10.1677/joe.0.1590239 10.1084/jem.154.3.631 10.1093/ajcn/36.6.1119 10.3181/00379727-170-41391 10.1159/000097228 10.1006/jsre.1995.1041 10.1042/cs0760659 |
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Keywords | Rat Corticosterone Body weight Cytokine Rodentia Corporal biometry Supplemented diet Metabolism Glucocorticoid Endotoxin Body composition Parenteral administration Feeding Vertebrata Mammalia Animal Adrenal hormone Lipopolysaccharide Tumor necrosis factor α |
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Snippet | Animals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy by total... We sought to investigate the nutritional and metabolic effects of bacterial lipopolysaccharide (LPS) in rats. BACKGROUNDAnimals treated with tumor necrosis factor alpha (TNF-alpha) developed severe metabolic abnormalities despite receiving sufficient protein and energy... |
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SubjectTerms | Animal Nutritional Physiological Phenomena Animals Bacteria Bacterial diseases Biological and medical sciences Corticosterone - blood DNA - analysis Eating Escherichia coli Experimental bacterial diseases and models Infectious diseases Lipopolysaccharides - pharmacology Male Medical sciences Metabolism Muscles - anatomy & histology Nutrition Organ Size Parenteral Nutrition, Total Proteins - analysis Rats Rats, Wistar Rodents Weight Loss |
Title | Nutritional and metabolic effects of the endotoxin bacterial lipopolysaccharide in orally and parenterally fed rats |
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