A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE

We have developed a number of hydroxamate and non-hydroxamate inhibitors of TACE that possess the selective quinolinemethoxy P1′ group. Using the X-ray co-crystal structure of our hydroxamate IK682 and TACE, and a co-crystal structure of a pyrimidinetrione in MMP-8, we have developed a highly plausi...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 17; no. 5; pp. 1408 - 1412
Main Authors Sheppeck, James E., Tebben, Andrew, Gilmore, John L., Yang, Anle, Wasserman, Zelda R., Decicco, Carl P., Duan, James J.-W.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.03.2007
Elsevier
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