Identification and characterization of bisbenzimide compounds that inhibit human cytomegalovirus replication

• Published in: Journal of general virology Vol. 102; no. 12
• Main Authors: Falci Finardi, Nicole, Kim, HyeongJun, Hernandez, Lee Z, Russell, Matthew R G, Ho, Catherine M-K, Sreenu, Vattipally B, Wenham, Hannah A, Merritt, Andy, Strang, Blair L
• Format: Journal Article
• Language: English
• Published: England Microbiology Society 09.12.2021
• Subjects: Animal; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Binding Sites; Bisbenzimidazole - chemistry; Bisbenzimidazole - pharmacology; Capsid - metabolism; Cell Line; Cytomegalovirus - drug effects; Cytomegalovirus - physiology; DNA - biosynthesis; DNA - chemistry; DNA Replication - drug effects; Humans; Molecular Structure; Viral Load - drug effects; Virus Replication - drug effects; human cytomegalovirus; bisbenzimide; drug

The shortcomings of current anti-human cytomegalovirus (HCMV) drugs has stimulated a search for anti-HCMV compounds with novel targets. We screened collections of bioactive compounds and identified a range of compounds with the potential to inhibit HCMV replication. Of these compounds, we selected b...