Transcriptional Effects of Psychoactive Drugs on Genes Involved in Neurogenesis

• Published in: International journal of molecular sciences Vol. 21; no. 21; p. 8333
• Main Authors: Bortolasci, Chiara C., Spolding, Briana, Kidnapillai, Srisaiyini, Connor, Timothy, Truong, Trang T.T., Liu, Zoe S.J., Panizzutti, Bruna, Richardson, Mark F., Gray, Laura, Berk, Michael, Dean, Olivia M., Walder, Ken
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 06.11.2020
• Subjects: Antipsychotic Agents - therapeutic use; Cell Line - drug effects; Databases, Genetic; Gene Expression - drug effects; Gene Ontology; Humans; Neurogenesis - drug effects; Neurogenesis - genetics; Psychotropic Drugs - metabolism; Psychotropic Drugs - pharmacology; SOXB1 Transcription Factors - genetics; Transcription, Genetic - drug effects; bipolar disorder; mental health; neuroscience; neurogenesis; psychiatry; schizophrenia; psychotropic drugs; neurons

Although neurogenesis is affected in several psychiatric diseases, the effects and mechanisms of action of psychoactive drugs on neurogenesis remain unknown and/or controversial. This study aims to evaluate the effects of psychoactive drugs on the expression of genes involved in neurogenesis. Neuron...