Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans - Zhang, Yueping; Holenarsipur, Vinay K.; Kandoussi, Hamza; Zeng, Jianing; Mariappan, T. Thanga; Sinz, Michael; Shen, Hong (Drug metabolism and disposition, 2020)
Keywords: Administration, Oral; Area Under Curve; Coproporphyrins - blood; Coproporphyrins - metabolism; Coproporphyrins - urine; Drug Interactions; Female; Furosemide - pharmacology; Healthy Volunteers; HEK293 Cells; Hepatocytes; Humans; Inhibitory Concentration 50; Liver-Specific Organic Anion Transporter 1 - antagonists & inhibitors; Liver-Specific Organic Anion Transporter 1 - metabolism; Male; Probenecid - pharmacology; Solute Carrier Organic Anion Transporter Family Member 1B3 - antagonists & inhibitors; Solute Carrier Organic Anion Transporter Family Member 1B3 - metabolism; FSM; FDA; E17βG; OAT; R-value; HDA; RIF SV; CLR; DDI; CPIII; MRP; OATP; AUC(0–24 h); CP; AUC; HEK; PROB; TDA; LC-MS/MS; RSV; CCK-8; HBSS; CPI