Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic disease...

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Published inInternational journal of molecular sciences Vol. 24; no. 1; p. 380
Main Authors Pojero, Fanny, Aiello, Anna, Gervasi, Francesco, Caruso, Calogero, Ligotti, Mattia Emanuela, Calabrò, Anna, Procopio, Antonio, Candore, Giuseppina, Accardi, Giulia, Allegra, Mario
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 26.12.2022
Subjects
Antioxidants - pharmacology
Antioxidants - therapeutic use
Humans
Inflammation - drug therapy
Inflammation Mediators
Iridoid Glucosides
Iridoids - pharmacology
Iridoids - therapeutic use
Olive Oil
Phenylethyl Alcohol - pharmacology
Review
inflammaging
hydroxytyrosol
oleuropein
nutraceutical
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Abstract Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
AbstractList Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
Author Caruso, Calogero
Ligotti, Mattia Emanuela
Procopio, Antonio
Candore, Giuseppina
Pojero, Fanny
Gervasi, Francesco
Aiello, Anna
Accardi, Giulia
Allegra, Mario
Calabrò, Anna
AuthorAffiliation 2 Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, Italy
3 Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
1 Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Technologies, University of Palermo, 90134 Palermo, Italy
4 Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123 Palermo, Italy
AuthorAffiliation_xml – name: 4 Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123 Palermo, Italy
– name: 1 Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Technologies, University of Palermo, 90134 Palermo, Italy
– name: 3 Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy
– name: 2 Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico Di Cristina e Benfratelli, 90127 Palermo, Italy
Author_xml – sequence: 1
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  orcidid: 0000-0002-4971-240X
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  fullname: Calabrò, Anna
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  orcidid: 0000-0003-3565-9529
  surname: Accardi
  fullname: Accardi, Giulia
– sequence: 10
  givenname: Mario
  orcidid: 0000-0002-5846-1868
  surname: Allegra
  fullname: Allegra, Mario
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36613822$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords inflammaging
hydroxytyrosol
oleuropein
nutraceutical
Language English
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These authors contributed equally to this work.
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Snippet Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system...
Aging is associated with a low-grade, systemic inflammatory state defined as "inflammaging", ruled by the loss of proper regulation of the immune system...
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SubjectTerms Antioxidants - pharmacology
Antioxidants - therapeutic use
Humans
Inflammation - drug therapy
Inflammation Mediators
Iridoid Glucosides
Iridoids - pharmacology
Iridoids - therapeutic use
Olive Oil
Phenylethyl Alcohol - pharmacology
Review
Title Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging
URI https://www.ncbi.nlm.nih.gov/pubmed/36613822
https://www.proquest.com/docview/2761981047
https://pubmed.ncbi.nlm.nih.gov/PMC9820525
Volume 24
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