Effects of Oleuropein and Hydroxytyrosol on Inflammatory Mediators: Consequences on Inflammaging

Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic disease...

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Published inInternational journal of molecular sciences Vol. 24; no. 1; p. 380
Main Authors Pojero, Fanny, Aiello, Anna, Gervasi, Francesco, Caruso, Calogero, Ligotti, Mattia Emanuela, Calabrò, Anna, Procopio, Antonio, Candore, Giuseppina, Accardi, Giulia, Allegra, Mario
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 26.12.2022
Subjects
Antioxidants - pharmacology
Antioxidants - therapeutic use
Humans
Inflammation - drug therapy
Inflammation Mediators
Iridoid Glucosides
Iridoids - pharmacology
Iridoids - therapeutic use
Olive Oil
Phenylethyl Alcohol - pharmacology
Review
inflammaging
hydroxytyrosol
oleuropein
nutraceutical
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Summary:Aging is associated with a low-grade, systemic inflammatory state defined as “inflammaging”, ruled by the loss of proper regulation of the immune system leading to the accumulation of pro-inflammatory mediators. Such a condition is closely connected to an increased risk of developing chronic diseases. A number of studies demonstrate that olive oil phenolic compound oleuropein and its derivative hydroxytyrosol contribute to modulating tissue inflammation and oxidative stress, thus becoming attractive potential candidates to be used in the context of nutraceutical interventions, in order to ameliorate systemic inflammation in aging subjects. In this review, we aim to summarize the available data about the anti-inflammatory properties of oleuropein and hydroxytyrosol, discussing them in the light of molecular pathways involved in the synthesis and release of inflammatory mediators in inflammaging.
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These authors contributed equally to this work.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24010380