Ultrasensitive Detection of Clostridioides difficile Toxins in Stool by Use of Single-Molecule Counting Technology: Comparison with Detection of Free Toxin by Cell Culture Cytotoxicity Neutralization Assay

• Published in: Journal of clinical microbiology Vol. 57; no. 11
• Main Authors: Hansen, Glen, Young, Stephen, Wu, Alan H. B., Herding, Emily, Nordberg, Vickie, Mills, Ray, Griego-Fullbright, Christen, Wagner, Aaron, Ong, Chui Mei, Lewis, Shawna, Yoon, Joseph, Estis, Joel, Sandlund, Johanna, Friedland, Emily, Carroll, Karen C.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2019
• Subjects: Bacteriology; single-molecule counting technology; ultrasensitive; ultrasensitivity; C. difficile; toxins A and B

Laboratory tests for Clostridioides difficile infection (CDI) rely on the detection of free toxin or molecular detection of toxin genes. The Singulex Clarity C. diff toxins A/B assay is a rapid, automated, and ultrasensitive assay that detects C. difficile toxins A and B in stool. We compared CDI as...