Ropinirole: For the treatment of Restless Legs syndrome

• Published in: CNS drugs Vol. 18; no. 11; pp. 747 - 756
• Main Authors: CHEER, Susan M, BANG, Lynne M, KEATING, Gillian M, ERNST, Michael E, WALTHER, Björn W, WETTER, Thomas C
• Format: Journal Article
• Language: English
• Published: Hong Kong Adis International 01.01.2004; Auckland Wolters Kluwer Health, Inc
• Subjects: Antiparkinson Agents - administration & dosage; Antiparkinson Agents - pharmacology; Antiparkinson Agents - therapeutic use; Biological and medical sciences; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Humans; Indoles - administration & dosage; Indoles - pharmacology; Indoles - therapeutic use; Medical sciences; Miscellaneous; Neuropharmacology; Pharmacology. Drug treatments; Restless Legs Syndrome - drug therapy; Human; Sensitivity disorder; Agonist; Nervous system diseases; Monograph; Review; Restless legs syndrome; Ropinirole; Chemotherapy; D2 Dopamine receptor; Treatment; Dopamine agonist; Neurological disorder; Mechanism of action; Pharmacokinetics

Ropinirole is a non-ergoline dopamine agonist that exhibits a high affinity for D(2) and D(3) receptors but little or no affinity for D(1)-like and non-dopaminergic receptors. Symptoms of restless legs syndrome (RLS) [measured using the International Restless Legs scale and Clinical Global Impressio...