Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes

• Published in: Infection and immunity Vol. 85; no. 10
• Main Authors: Dankwa, Selasi, Chaand, Mudit, Kanjee, Usheer, Jiang, Rays H. Y., Nobre, Luis V., Goldberg, Jonathan M., Bei, Amy K., Moechtar, Mischka A., Grüring, Christof, Ahouidi, Ambroise D., Ndiaye, Daouda, Dieye, Tandakha N., Mboup, Souleymane, Weekes, Michael P., Duraisingh, Manoj T.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.10.2017
• Subjects: Computational Biology; Erythrocytes - parasitology; Erythrocytes - physiology; Glycophorin - genetics; Glycophorin - metabolism; Humans; Ligands; Molecular Pathogenesis; Plasmodium falciparum - immunology; Plasmodium falciparum - pathogenicity; Plasmodium falciparum - physiology; Protein Binding; Proteomics; Receptors, Cell Surface - metabolism; red blood cells; Plasmodium falciparum; host cell invasion; glycophorin; malaria; cultured erythrocyte; transcriptional variation

Plasmodium falciparum , the parasite that causes the deadliest form of malaria, has evolved multiple proteins known as invasion ligands that bind to specific erythrocyte receptors to facilitate invasion of human erythrocytes. The EBA-175/glycophorin A (GPA) and Rh5/basigin ligand-receptor interactio...