Thrombotic Thrombocytopenic Purpura: aetiology, pathophysiology and treatment
Thrombotic thrombocytopenic purpura (TTP) is a rare disorder whose varied clinical manifestations result from the formation of platelet-rich thrombi within the microvasculature and consequent tissue ischaemia. This review will outline how, in the eighty years since its initial description, scientifi...
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| Published in | Blood reviews Vol. 20; no. 1; pp. 51 - 60 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Kent
Elsevier Ltd
2006
Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Thrombotic thrombocytopenic purpura (TTP) is a rare disorder whose varied clinical manifestations result from the formation of platelet-rich thrombi within the microvasculature and consequent tissue ischaemia.
This review will outline how, in the eighty years since its initial description, scientific discoveries have not only led to a deeper understanding of the fundamental pathophysiology of TTP, but have also contributed to advances in the clinical management of this condition.
Current research in this field will hopefully provide the basis for the design and development of novel therapeutic strategies. |
|---|---|
| AbstractList | Thrombotic thrombocytopenic purpura (TTP) is a rare disorder whose varied clinical manifestations result from the formation of platelet-rich thrombi within the microvasculature and consequent tissue ischaemia. This review will outline how, in the eighty years since its initial description, scientific discoveries have not only led to a deeper understanding of the fundamental pathophysiology of TTP, but have also contributed to advances in the clinical management of this condition. Current research in this field will hopefully provide the basis for the design and development of novel therapeutic strategies. Thrombotic thrombocytopenic purpura (TTP) is a rare disorder whose varied clinical manifestations result from the formation of platelet-rich thrombi within the microvasculature and consequent tissue ischaemia. This review will outline how, in the eighty years since its initial description, scientific discoveries have not only led to a deeper understanding of the fundamental pathophysiology of TTP, but have also contributed to advances in the clinical management of this condition. Current research in this field will hopefully provide the basis for the design and development of novel therapeutic strategies. |
| Author | Murray, J.A. Murrin, R.J.A. |
| Author_xml | – sequence: 1 givenname: R.J.A. surname: Murrin fullname: Murrin, R.J.A. email: richard.murrin2@swbh.nhs.uk organization: Department of Haematology, Sandwell General Hospital, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands, UK – sequence: 2 givenname: J.A. surname: Murray fullname: Murray, J.A. organization: Department of Haematology, Selly Oak Hospital, University Hospital of Birmingham, NHS Foundation Trust, UK |
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| Keywords | Thrombotic thrombocytopenic purpura Treatment Review Pathophysiology Aetiology Skin disease Nervous system diseases Urinary system disease Hematology Vascular disorders of the skin Cardiovascular disease Hemopathy Vascular disease Platelet Hemolytic anemia Etiology Capillary vessel disease Coagulopathy |
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| SubjectTerms | Aetiology Anemias. Hemoglobinopathies Biological and medical sciences Diseases of red blood cells Female Hematologic and hematopoietic diseases Humans Male Medical sciences Pathophysiology Plasmapheresis Platelet diseases and coagulopathies Purpura, Thrombotic Thrombocytopenic - etiology Purpura, Thrombotic Thrombocytopenic - physiopathology Purpura, Thrombotic Thrombocytopenic - therapy Recurrence Review Thrombotic thrombocytopenic purpura Treatment von Willebrand Factor - physiology |
| Title | Thrombotic Thrombocytopenic Purpura: aetiology, pathophysiology and treatment |
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