The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

• Published in: International journal of molecular sciences Vol. 21; no. 24; p. 9739
• Main Authors: Cabral-Pacheco, Griselda A, Garza-Veloz, Idalia, Castruita-De la Rosa, Claudia, Ramirez-Acuña, Jesús M, Perez-Romero, Braulio A, Guerrero-Rodriguez, Jesús F, Martinez-Avila, Nadia, Martinez-Fierro, Margarita L
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 20.12.2020
• Subjects: Chronic Disease - prevention & control; Diabetes Mellitus - genetics; Diabetes Mellitus - pathology; Extracellular Matrix - genetics; Humans; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinases - genetics; Neovascularization, Physiologic - genetics; Review; Tissue Inhibitor of Metalloproteinase-1 - genetics; Tissue Inhibitor of Metalloproteinase-3; Tissue Inhibitor of Metalloproteinases - genetics; matrix metalloproteinases; metalloproteinase inhibitors; human diseases

Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis....