Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets

• Published in: The Journal of experimental medicine Vol. 217; no. 3
• Main Authors: Ghaedi, Maryam, Shen, Zi Yi, Orangi, Mona, Martinez-Gonzalez, Itziar, Wei, Lisa, Lu, Xiaoxiao, Das, Arundhoti, Heravi-Moussavi, Alireza, Marra, Marco A, Bhandoola, Avinash, Takei, Fumio
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 02.03.2020
• Subjects: Amphiregulin - immunology; Animals; Cell Differentiation - immunology; Cell Lineage - immunology; Cytokines - immunology; Immunity, Innate - immunology; Inflammation - immunology; Lung - immunology; Lymphocytes - immunology; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 1 - immunology; Single-Cell Analysis - methods; Stem Cells - immunology

Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue repair. ILC2 development is dependent on the transcription factor retinoic acid receptor-related orphan receptor (RORα), which is also expressed in common ILC progenitors. To elucidate the developmental pathway...