Increased mortality in septic shock with the 4G/4G genotype of plasminogen activator inhibitor 1 in patients of white descent

• Published in: Intensive care medicine Vol. 33; no. 8; pp. 1354 - 1362
• Main Authors: García-Segarra, Gloria, Espinosa, Gerard, Tassies, Dolors, Oriola, Josep, Aibar, Jesús, Bové, Albert, Castro, Pedro, Reverter, Joan-Carles, Nicolás, Josep-Maria
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.08.2007; Berlin Springer Nature B.V
• Subjects: Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antigens; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Blood. Blood coagulation. Reticuloendothelial system; Dimers; Epidemiology; Failure; Female; Gene polymorphism; Genotype & phenotype; Genotyping; Homozygotes; Hospital Mortality; Hospitals; Humans; Infections; Inflammation; Inflammatory response; Intensive care; Intensive care medicine; Intensive Care Units; Interleukin 1; Male; Medical Records; Medical sciences; Middle Aged; Mortality; Multiple Organ Failure - genetics; Patients; Pharmacology. Drug treatments; Physiology; Plasminogen Activator Inhibitor 1 - genetics; Plasminogen activator inhibitors; Polymorphism; Polymorphism, Genetic; Sepsis; Septic shock; Shock, Septic - genetics; Shock, Septic - mortality; Spain; Systemic inflammatory response syndrome; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Tumor necrosis factor; Tumor necrosis factor-TNF; Whites - genetics; Spain; Shock; Human; Septic shock, Organ failure, Fibrinolysis; Intensive care; Mortality; Genotype; Polymorphisms; Fibrinolysis; Infection; Plasminogen activator inhibitor 1; Plasminogen; Caucasoid; Resuscitation; Polymorphism

To evaluate the effect of the 4G/5G PAI-1 gene polymorphism on the development of organ failure and outcome in critically ill patients with septic syndromes. Prospective, observational study in a medical intensive care unit of a university hospital. 224 consecutively admitted patients. Epidemiologic...