The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology

• Published in: Molecular and cellular neuroscience Vol. 47; no. 4; pp. 265 - 273
• Main Authors: Round, Jennifer E., Sun, Hui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2011
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Cell Shape; Cells, Cultured; Cerebral Cortex - cytology; Cortical neuron; Cytoskeleton - metabolism; Dendrite; Female; HEK293 Cells; Humans; Mice; Mice, Knockout; Nck; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurons - cytology; Neurons - physiology; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Pregnancy; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; RNA Interference; Robo; Roundabout Proteins; SH2/SH3 adaptor; Signal Transduction - physiology; Slit; Cortical neuron; Slit; SH2/SH3 adaptor; Robo; Nck; Dendrite

Slits are multifunctional guidance cues, capable of triggering neurite repulsion, extension, or branching, depending on cell type and developmental context. While the Robo family of Slit receptors is a well-established mediator of axon repulsion, a role for Robos in Slit-mediated neurite growth and...