HIV-1 Reservoir Dynamics after Vaccination and Antiretroviral Therapy Interruption Are Associated with Dendritic Cell Vaccine-Induced T Cell Responses

• Published in: Journal of virology Vol. 89; no. 18; pp. 9189 - 9199
• Main Authors: Andrés, Cristina, Plana, Montserrat, Guardo, Alberto C., Alvarez-Fernández, Carmen, Climent, Nuria, Gallart, Teresa, León, Agathe, Clotet, Bonaventura, Autran, Brigitte, Chomont, Nicolas, Gatell, Josep M., Sánchez-Palomino, Sonsoles, García, Felipe
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2015
• Subjects: Adult; AIDS Vaccines - administration & dosage; AIDS Vaccines - genetics; AIDS Vaccines - immunology; Anti-Retroviral Agents - administration & dosage; Autografts; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - immunology; Dendritic Cells - immunology; Dendritic Cells - transplantation; Female; HIV Infections - immunology; HIV Infections - therapy; HIV-1 - genetics; HIV-1 - immunology; Humans; Male; Middle Aged; Vaccination; Vaccines and Antiviral Agents; Vaccines, DNA - administration & dosage; Vaccines, DNA - genetics; Vaccines, DNA - immunology

HIV-1-specific immune responses induced by a dendritic cell (DC)-based therapeutic vaccine might have some effect on the viral reservoir. Patients on combination antiretroviral therapy (cART) were randomized to receive DCs pulsed with autologous HIV-1 ( n = 24) (DC-HIV-1) or nonpulsed DCs ( n = 12)...