Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells
The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells. Arteries and cord blood were obtained from 5 term pregnancies undergoing repeat cesarean sectio...
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| Published in | American journal of obstetrics and gynecology Vol. 195; no. 4; pp. 1015 - 1019 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article Conference Proceeding |
| Language | English |
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Philadelphia, PA
Mosby, Inc
01.10.2006
Elsevier |
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| Abstract | The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells.
Arteries and cord blood were obtained from 5 term pregnancies undergoing repeat cesarean section. Maternal blood was obtained from another 6 women at 16 to 20 weeks' gestation. Tissues were fractionated by dissection or Histopaque gradient. Specimens were incubated in physiologic media then exposed to lipopolysaccharide (LPS) or P4 alone, or pretreated with P4 and then exposed to LPS. Samples were evaluated for IL-6 by enzyme-linked immunosorbent assay (ELISA).
Arteries and fetal and maternal mononuclear cells exposed to LPS increased IL-6 secretion by 9-, 27-, and 29-fold, respectively. P4 pretreatment blocked LPS induction of IL-6. Fetal granulocytes did not increase IL-6 production in response to LPS exposure.
LPS induces IL-6 in arteries and fetal and maternal mononuclear cells. P4 pretreatment significantly blocks this effect in these cell populations, suggesting possible targets for anti-inflammatory actions of P4 in prevention of preterm birth. |
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| AbstractList | The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells.
Arteries and cord blood were obtained from 5 term pregnancies undergoing repeat cesarean section. Maternal blood was obtained from another 6 women at 16 to 20 weeks' gestation. Tissues were fractionated by dissection or Histopaque gradient. Specimens were incubated in physiologic media then exposed to lipopolysaccharide (LPS) or P4 alone, or pretreated with P4 and then exposed to LPS. Samples were evaluated for IL-6 by enzyme-linked immunosorbent assay (ELISA).
Arteries and fetal and maternal mononuclear cells exposed to LPS increased IL-6 secretion by 9-, 27-, and 29-fold, respectively. P4 pretreatment blocked LPS induction of IL-6. Fetal granulocytes did not increase IL-6 production in response to LPS exposure.
LPS induces IL-6 in arteries and fetal and maternal mononuclear cells. P4 pretreatment significantly blocks this effect in these cell populations, suggesting possible targets for anti-inflammatory actions of P4 in prevention of preterm birth. OBJECTIVEThe purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells.STUDY DESIGNArteries and cord blood were obtained from 5 term pregnancies undergoing repeat cesarean section. Maternal blood was obtained from another 6 women at 16 to 20 weeks' gestation. Tissues were fractionated by dissection or Histopaque gradient. Specimens were incubated in physiologic media then exposed to lipopolysaccharide (LPS) or P4 alone, or pretreated with P4 and then exposed to LPS. Samples were evaluated for IL-6 by enzyme-linked immunosorbent assay (ELISA).RESULTSArteries and fetal and maternal mononuclear cells exposed to LPS increased IL-6 secretion by 9-, 27-, and 29-fold, respectively. P4 pretreatment blocked LPS induction of IL-6. Fetal granulocytes did not increase IL-6 production in response to LPS exposure.CONCLUSIONLPS induces IL-6 in arteries and fetal and maternal mononuclear cells. P4 pretreatment significantly blocks this effect in these cell populations, suggesting possible targets for anti-inflammatory actions of P4 in prevention of preterm birth. The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal granulocytes, and fetal and maternal mononuclear cells. Arteries and cord blood were obtained from 5 term pregnancies undergoing repeat cesarean section. Maternal blood was obtained from another 6 women at 16 to 20 weeks' gestation. Tissues were fractionated by dissection or Histopaque gradient. Specimens were incubated in physiologic media then exposed to lipopolysaccharide (LPS) or P4 alone, or pretreated with P4 and then exposed to LPS. Samples were evaluated for IL-6 by enzyme-linked immunosorbent assay (ELISA). Arteries and fetal and maternal mononuclear cells exposed to LPS increased IL-6 secretion by 9-, 27-, and 29-fold, respectively. P4 pretreatment blocked LPS induction of IL-6. Fetal granulocytes did not increase IL-6 production in response to LPS exposure. LPS induces IL-6 in arteries and fetal and maternal mononuclear cells. P4 pretreatment significantly blocks this effect in these cell populations, suggesting possible targets for anti-inflammatory actions of P4 in prevention of preterm birth. |
| Author | Gotkin, Jennifer L. McNutt, Patrick Celver, Jeremy Napolitano, Peter G. Shields, Andrea D. Howard, Bobby C. Paonessa, Damian J. |
| Author_xml | – sequence: 1 givenname: Jennifer L. surname: Gotkin fullname: Gotkin, Jennifer L. email: jennifer.gotkin@amedd.army.mil organization: Division of Maternal-Fetal Medicine – sequence: 2 givenname: Jeremy surname: Celver fullname: Celver, Jeremy organization: Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA – sequence: 3 givenname: Patrick surname: McNutt fullname: McNutt, Patrick organization: Department of Clinical Investigation, Madigan Army Medical Center, Tacoma, WA – sequence: 4 givenname: Andrea D. surname: Shields fullname: Shields, Andrea D. organization: Division of Maternal-Fetal Medicine – sequence: 5 givenname: Bobby C. surname: Howard fullname: Howard, Bobby C. organization: Division of Maternal-Fetal Medicine – sequence: 6 givenname: Damian J. surname: Paonessa fullname: Paonessa, Damian J. organization: Division of Maternal-Fetal Medicine – sequence: 7 givenname: Peter G. surname: Napolitano fullname: Napolitano, Peter G. organization: Division of Maternal-Fetal Medicine |
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| Cites_doi | 10.1016/0022-1759(74)90109-4 10.1016/S0002-9378(98)70272-8 10.1016/S0898-6568(00)00149-2 10.1016/j.ajog.2003.10.693 10.1097/01.AOG.0000114980.40445.83 10.1016/j.ajog.2005.05.046 10.1056/NEJMoa035140 10.1001/jama.292.4.462 10.1067/mob.2003.41 |
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| Keywords | Inflammation Progesterone Cytokines Fetal artery Interleukin-6 Blood Progestagen Interleukin 6 Mononuclear cell Mother Blood vessel Lipopolysaccharide Fetus Secretion Gynecology Cytokine Chorion Obstetrics Ovarian hormone Artery Pregnancy Blood cell Circulatory system Umbilical cord Sex steroid hormone |
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| References | Shields, Wright, Paonessa, Gotkin, Howard, Hoeldtke (bib7) 2005; 193 Boyum (bib9) 1968; 21 Meis, Klebanoff, Thom, Dombrowski, Sibai, Moawad (bib1) 2003; 348 (bib8) 2004 Gravett, Novy, Rosenfeld, Reddy, Jacob, Turner (bib3) 2004; 292 English, Andersen (bib10) 1974; 5 Gomez, Romero, Ghezzi, Yoon, Mazor, Berry (bib2) 1998; 179 da Fonseca, Bittar, Carvalho, Zugaib (bib6) 2003; 188 Zaretsky, Alexander, Byrd, Bawdon (bib4) 2004; 103 Guha, Mackman (bib11) 2001; 13 Elovitz, Wang (bib5) 2004; 190 Shields (10.1016/j.ajog.2006.07.002_bib7) 2005; 193 Gomez (10.1016/j.ajog.2006.07.002_bib2) 1998; 179 English (10.1016/j.ajog.2006.07.002_bib10) 1974; 5 Meis (10.1016/j.ajog.2006.07.002_bib1) 2003; 348 Gravett (10.1016/j.ajog.2006.07.002_bib3) 2004; 292 Elovitz (10.1016/j.ajog.2006.07.002_bib5) 2004; 190 Guha (10.1016/j.ajog.2006.07.002_bib11) 2001; 13 da Fonseca (10.1016/j.ajog.2006.07.002_bib6) 2003; 188 Boyum (10.1016/j.ajog.2006.07.002_bib9) 1968; 21 Zaretsky (10.1016/j.ajog.2006.07.002_bib4) 2004; 103 (10.1016/j.ajog.2006.07.002_bib8) 2004 |
| References_xml | – volume: 13 start-page: 85 year: 2001 end-page: 94 ident: bib11 article-title: LPS induction of gene expression in human monocytes publication-title: Cell Signal contributor: fullname: Mackman – volume: 292 start-page: 462 year: 2004 end-page: 469 ident: bib3 article-title: Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers publication-title: JAMA contributor: fullname: Turner – year: 2004 ident: bib8 article-title: Physician's drug reference, 58th ed – volume: 179 start-page: 194 year: 1998 end-page: 202 ident: bib2 article-title: The fetal inflammatory response syndrome publication-title: Am J Obstet Gynecol contributor: fullname: Berry – volume: 21 start-page: 77 year: 1968 ident: bib9 article-title: Separation of leukocytes from blood and bone marrow publication-title: Scand J Clin Lab Invest contributor: fullname: Boyum – volume: 103 start-page: 546 year: 2004 end-page: 550 ident: bib4 article-title: Transfer of inflammatory cytokines across the placenta publication-title: Obstet Gynecol contributor: fullname: Bawdon – volume: 348 start-page: 2379 year: 2003 end-page: 2385 ident: bib1 article-title: Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate publication-title: N Engl J Med contributor: fullname: Moawad – volume: 190 start-page: 693 year: 2004 end-page: 701 ident: bib5 article-title: Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise publication-title: Am J Obstet Gynecol contributor: fullname: Wang – volume: 193 start-page: 1144 year: 2005 end-page: 1148 ident: bib7 article-title: Progesterone modulation of inflammatory cytokine production in a fetoplacental artery explant model publication-title: Am J Obstet Gynecol contributor: fullname: Hoeldtke – volume: 5 start-page: 249 year: 1974 end-page: 252 ident: bib10 article-title: Single-step separation of red blood cells. 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Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque publication-title: J Immun Meth doi: 10.1016/0022-1759(74)90109-4 contributor: fullname: English – volume: 21 start-page: 77 issue: suppl 97 year: 1968 ident: 10.1016/j.ajog.2006.07.002_bib9 article-title: Separation of leukocytes from blood and bone marrow publication-title: Scand J Clin Lab Invest contributor: fullname: Boyum – volume: 179 start-page: 194 year: 1998 ident: 10.1016/j.ajog.2006.07.002_bib2 article-title: The fetal inflammatory response syndrome publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(98)70272-8 contributor: fullname: Gomez – volume: 13 start-page: 85 year: 2001 ident: 10.1016/j.ajog.2006.07.002_bib11 article-title: LPS induction of gene expression in human monocytes publication-title: Cell Signal doi: 10.1016/S0898-6568(00)00149-2 contributor: fullname: Guha – volume: 190 start-page: 693 year: 2004 ident: 10.1016/j.ajog.2006.07.002_bib5 article-title: Medroxyprogesterone acetate, but not progesterone, protects against inflammation-induced parturition and intrauterine fetal demise publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2003.10.693 contributor: fullname: Elovitz – volume: 103 start-page: 546 year: 2004 ident: 10.1016/j.ajog.2006.07.002_bib4 article-title: Transfer of inflammatory cytokines across the placenta publication-title: Obstet Gynecol doi: 10.1097/01.AOG.0000114980.40445.83 contributor: fullname: Zaretsky – volume: 193 start-page: 1144 year: 2005 ident: 10.1016/j.ajog.2006.07.002_bib7 article-title: Progesterone modulation of inflammatory cytokine production in a fetoplacental artery explant model publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2005.05.046 contributor: fullname: Shields – volume: 348 start-page: 2379 year: 2003 ident: 10.1016/j.ajog.2006.07.002_bib1 article-title: Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate publication-title: N Engl J Med doi: 10.1056/NEJMoa035140 contributor: fullname: Meis – volume: 292 start-page: 462 year: 2004 ident: 10.1016/j.ajog.2006.07.002_bib3 article-title: Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers publication-title: JAMA doi: 10.1001/jama.292.4.462 contributor: fullname: Gravett – volume: 188 start-page: 419 year: 2003 ident: 10.1016/j.ajog.2006.07.002_bib6 article-title: Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study publication-title: Am J Obstet Gynecol doi: 10.1067/mob.2003.41 contributor: fullname: da Fonseca – year: 2004 ident: 10.1016/j.ajog.2006.07.002_bib8 |
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| Snippet | The purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal... OBJECTIVEThe purpose of this study was to characterize effect of progesterone (P4) on interleukin-6 (IL-6) production by fetoplacental artery explants, fetal... |
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| SubjectTerms | Arteries - drug effects Arteries - metabolism Biological and medical sciences Chorion - blood supply Cytokines Female Fetal artery Fetal Blood - drug effects Fetal Blood - metabolism Gynecology. Andrology. Obstetrics Humans Inflammation Interleukin-6 Interleukin-6 - biosynthesis Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lipopolysaccharides - pharmacology Medical sciences Pregnancy Progesterone Progesterone - pharmacology Tumor Necrosis Factor-alpha - biosynthesis |
| Title | Progesterone reduces lipopolysaccharide induced interleukin-6 secretion in fetoplacental chorionic arteries, fractionated cord blood, and maternal mononuclear cells |
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