Assessment of Response to Neoadjuvant Therapy Using CT Texture Analysis in Patients With Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma

• Published in: American journal of roentgenology (1976) Vol. 214; no. 2; pp. 362 - 369
• Main Authors: Borhani, Amir A., Dewan, Rohit, Furlan, Alessandro, Seiser, Natalie, Zureikat, Amer H., Singhi, Aatur D., Boone, Brian, Bahary, Nathan, Hogg, Melissa E., Lotze, Michael, III, Herbert J. Zeh, Tublin, Mitchell E.
• Format: Journal Article
• Language: English
• Published: United States 01.02.2020
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Pancreatic Ductal - diagnostic imaging; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Pancreatic Ductal - therapy; Contrast Media; Disease-Free Survival; Female; Humans; Iopamidol; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Grading; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - therapy; Prospective Studies; Radiographic Image Interpretation, Computer-Assisted; Tomography, X-Ray Computed; CT; neoadjuvant chemotherapy; pancreatic adenocarcinoma; pancreatic cancer; texture analysis

The goal of this study was to assess the correlation between CT-derived texture features of pancreatic ductal adenocarcinoma (PDAC) and histologic and biochemical markers of response to neoadjuvant treatment as well as disease-free survival in patients with potentially resectable PDAC. Thirty-nine p...