Triptan use and risk of cardiovascular events: a nested-case-control study from the French health system database

• Published in: European journal of clinical pharmacology Vol. 63; no. 8; pp. 801 - 807
• Main Authors: Lugardon, S., Roussel, H., Sciortino, V., Montastruc, J. L., Lapeyre-Mestre, M.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.08.2007; Berlin Springer Nature B.V
• Subjects: Adult; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - epidemiology; Cardiovascular system; Case-Control Studies; Cohort Studies; Databases, Factual; Drug therapy; Drug Utilization - statistics & numerical data; Female; France - epidemiology; Headache; Health care; Heart; Humans; Ischemia; Male; Medical sciences; Middle Aged; Migraine; Migraine Disorders - drug therapy; Patients; Pharmacology; Pharmacology. Drug treatments; Risk; Risk factors; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists - adverse effects; Serotonin Receptor Agonists - therapeutic use; Side effects; Tryptamines - adverse effects; Tryptamines - therapeutic use; France; Europe; Vascular disease; Human; Health system; Overuse·Triptans; Ischemia; Atherosclerosis; Cardiovascular risk; Database; Triptan derivatives; Cardiovascular events Ischemic event; Cardiovascular disease; Case control study

The use of triptans (5-HT agonists) in the treatment of migraine is associated with a potential increasing risk of cardiovascular events and raises the question of the relationship between overuse and the occurrence of ischemic events. The aim of this study was to examine the association between the...