Triptan use and risk of cardiovascular events: a nested-case-control study from the French health system database

• Published in: European journal of clinical pharmacology Vol. 63; no. 8; pp. 801 - 807
• Main Authors: Lugardon, S., Roussel, H., Sciortino, V., Montastruc, J. L., Lapeyre-Mestre, M.
• Format: Journal Article
• Language: English
• Published: Heidelberg Springer 01.08.2007; Berlin Springer Nature B.V
• Subjects: Adult; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - chemically induced; Cardiovascular Diseases - epidemiology; Cardiovascular system; Case-Control Studies; Cohort Studies; Databases, Factual; Drug therapy; Drug Utilization - statistics & numerical data; Female; France - epidemiology; Headache; Health care; Heart; Humans; Ischemia; Male; Medical sciences; Middle Aged; Migraine; Migraine Disorders - drug therapy; Patients; Pharmacology; Pharmacology. Drug treatments; Risk; Risk factors; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists - adverse effects; Serotonin Receptor Agonists - therapeutic use; Side effects; Tryptamines - adverse effects; Tryptamines - therapeutic use; France; Europe; Vascular disease; Human; Health system; Overuse·Triptans; Ischemia; Atherosclerosis; Cardiovascular risk; Database; Triptan derivatives; Cardiovascular events Ischemic event; Cardiovascular disease; Case control study
• DOI: 10.1007/s00228-007-0332-2
• ISSN: 0031-6970

The use of triptans (5-HT agonists) in the treatment of migraine is associated with a potential increasing risk of cardiovascular events and raises the question of the relationship between overuse and the occurrence of ischemic events. The aim of this study was to examine the association between the intensity of triptan use and occurrence of an cardiac event. Using the reimbursed drug prescription database of the National French Health Insurance System in the Midi-Pyrenees area, we identified subjects receiving at least one triptan in the second semester of 2002. From this population, we selected new users and retrieved all reimbursed care data up to 31 December 2003. We estimated the patterns of triptan exposure by calculating the number of defined daily doses (DDD) received per 30-day period. Another reimbursed health care database was used to identify as cases of cardiac outcomes those patients receiving care for the management of a possible heart ischemic event. Each case was randomly matched on age and gender with four controls free of any cardiovascular event before the index date. A conditional logistic regression was performed to assess the relationship between cardiac outcomes and exposure to triptans in the 30 days before the index date. The cohort of new users of triptans included 8625 subjects, 4414 (51.18%) of whom received only one dispensation for triptans during the follow-up period (median duration: 427 days). For the remaining subjects, the peak of triptans delivery was </=8 DDD for 14.68% of the cohort, between 9 and 14 DDD for 22.17%, between 15 and 29 for 10.04% and >/=30 DDD for 1.92%. Fifty-seven users (0.66%) presented a cardiac history and 1388 patients (16.09%) had cardiovascular risk factors. We identified 155 incident cases of cardiac outcomes during the follow-up and compared these to 620 matched controls. Cases were older and presented more frequently with cardiac history or cardiovascular risk factors than the other users of triptans. The distribution exposure to triptans did not significantly differ between cases and controls with an odds ratio for an exposure </=8 DDD in the last 30 days of 0.74 [95% CI (0.31-1.77)] and that for an exposure >8 DDD equal to 1.14 [95% CI (0.58-2.27)]. The proportion of patients showing an overuse of triptans (more than 15 DDD for 30 days) reached 12% in this cohort of new users of triptans. However, we did not find any relationship between the overuse of triptans and cardiac outcomes. This study also shows that some patients with cardiovascular risk factors are actually treated by triptans. These patients are more likely to present a cardiac outcome potentially related to an ischemic event after the introduction of triptan.