Identification and characterization of stem cells in mammalian esophageal stratified squamous epithelia

• Published in: Journal of molecular cell biology Vol. 14; no. 6
• Main Authors: Yang, Yanan, Deng, Guodong, Qiao, Lili, Yuan, Hui, Yu, Xiaohong, Xu, Lei, Lu, Shih-Hsin, Jiang, Wei, Yu, Xiying
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 17.11.2022
• Subjects: Animals; Carcinoma, Squamous Cell - metabolism; Cell Differentiation; Cell Proliferation; Epithelium - metabolism; Esophagus - metabolism; Mammals; Rats; Stem Cells - metabolism; Wnt Signaling Pathway; esophageal stem cells; homeostasis; hemidesmosomes; Wnt signaling

Somatic stem cells are essential for the maintenance of tissue homeostasis. Despite its importance, how the esophageal stratified squamous epithelium executes its self-renewal and maintenance remains elusive. In this study, using 5-bromo-2'-deoxyuridine label-chase in rats in vivo and rat esoph...