Dynamic conformal arc cranial stereotactic radiosurgery: implications of multileaf collimator margin on dose-volume metrics
The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed. 118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment pl...
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Published in | British journal of radiology Vol. 85; no. 1019; pp. e1058 - e1066 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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England
The British Institute of Radiology
01.11.2012
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Abstract | The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed.
118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of -1, 0, 1, 2 and 3 mm, respectively. Identical treatment planning parameters were employed with a median of five dynamic conformal arcs using the Varian/BrainLab high-definition MLC for beam shaping. Prescription dose (PD) was such that 22 Gy covered at least 95% of the PTV. Dose-volume and dose-response comparative metrics included conformity index, heterogeneity index, dose gradient, tumour control probability (TCP) and normal tissue complication probability (NTCP).
Target dose heterogeneity decreased with increasing MLC margin (p<0.001); mean heterogeneity index decreased from 70.4 ± 12.7 to 10.4 ± 2.2%. TCP decreased with increasing MLC margin (p<0.001); mean TCP decreased from 81.0 ± 2.3 to 62.2 ± 1.8%. Normal tissue dose fall-off increased with MLC margin (p<0.001); mean gradient increased from 3.1 ± 0.9 mm to 5.3 ± 0.7 mm. NTCP was optimal at 1 mm MLC margin. No unambiguous correlation was observed between NTCP and PTV volume. Plan delivery efficiency generally improved with larger margins (p<0.001); mean monitor unit per centigray of the PD decreased from 3.60 ± 1.30 to 1.56 ± 0.13. Conclusion Use of 1 mm MLC margins for dynamic conformal arc-based cranial radiosurgery resulted in optimal tumour control and normal tissue sparing. Clinical significance of these comparative findings warrants further investigation. |
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AbstractList | The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed.
118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of -1, 0, 1, 2 and 3 mm, respectively. Identical treatment planning parameters were employed with a median of five dynamic conformal arcs using the Varian/BrainLab high-definition MLC for beam shaping. Prescription dose (PD) was such that 22 Gy covered at least 95% of the PTV. Dose-volume and dose-response comparative metrics included conformity index, heterogeneity index, dose gradient, tumour control probability (TCP) and normal tissue complication probability (NTCP).
Target dose heterogeneity decreased with increasing MLC margin (p<0.001); mean heterogeneity index decreased from 70.4 ± 12.7 to 10.4 ± 2.2%. TCP decreased with increasing MLC margin (p<0.001); mean TCP decreased from 81.0 ± 2.3 to 62.2 ± 1.8%. Normal tissue dose fall-off increased with MLC margin (p<0.001); mean gradient increased from 3.1 ± 0.9 mm to 5.3 ± 0.7 mm. NTCP was optimal at 1 mm MLC margin. No unambiguous correlation was observed between NTCP and PTV volume. Plan delivery efficiency generally improved with larger margins (p<0.001); mean monitor unit per centigray of the PD decreased from 3.60 ± 1.30 to 1.56 ± 0.13. Conclusion Use of 1 mm MLC margins for dynamic conformal arc-based cranial radiosurgery resulted in optimal tumour control and normal tissue sparing. Clinical significance of these comparative findings warrants further investigation. Objective The effect of multileaf collimator (MLC) margin on target and normal tissue dose–volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed. Methods 118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of −1, 0, 1, 2 and 3 mm, respectively. Identical treatment planning parameters were employed with a median of five dynamic conformal arcs using the Varian/BrainLab high-definition MLC for beam shaping. Prescription dose (PD) was such that 22 Gy covered at least 95% of the PTV. Dose–volume and dose–response comparative metrics included conformity index, heterogeneity index, dose gradient, tumour control probability (TCP) and normal tissue complication probability (NTCP). Results Target dose heterogeneity decreased with increasing MLC margin (p<0.001); mean heterogeneity index decreased from 70.4±12.7 to 10.4±2.2%. TCP decreased with increasing MLC margin (p<0.001); mean TCP decreased from 81.0±2.3 to 62.2±1.8%. Normal tissue dose fall-off increased with MLC margin (p<0.001); mean gradient increased from 3.1±0.9 mm to 5.3±0.7 mm. NTCP was optimal at 1 mm MLC margin. No unambiguous correlation was observed between NTCP and PTV volume. Plan delivery efficiency generally improved with larger margins (p<0.001); mean monitor unit per centigray of the PD decreased from 3.60±1.30 to 1.56±0.13. Conclusion Use of 1 mm MLC margins for dynamic conformal arc-based cranial radiosurgery resulted in optimal tumour control and normal tissue sparing. Clinical significance of these comparative findings warrants further investigation. OBJECTIVEThe effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed.METHODS118 intracranial lesions of 83 SRS patients formed the basis of this study. For each planning target volume (PTV), five separate treatment plans were generated with MLC margins of -1, 0, 1, 2 and 3 mm, respectively. Identical treatment planning parameters were employed with a median of five dynamic conformal arcs using the Varian/BrainLab high-definition MLC for beam shaping. Prescription dose (PD) was such that 22 Gy covered at least 95% of the PTV. Dose-volume and dose-response comparative metrics included conformity index, heterogeneity index, dose gradient, tumour control probability (TCP) and normal tissue complication probability (NTCP).RESULTSTarget dose heterogeneity decreased with increasing MLC margin (p<0.001); mean heterogeneity index decreased from 70.4 ± 12.7 to 10.4 ± 2.2%. TCP decreased with increasing MLC margin (p<0.001); mean TCP decreased from 81.0 ± 2.3 to 62.2 ± 1.8%. Normal tissue dose fall-off increased with MLC margin (p<0.001); mean gradient increased from 3.1 ± 0.9 mm to 5.3 ± 0.7 mm. NTCP was optimal at 1 mm MLC margin. No unambiguous correlation was observed between NTCP and PTV volume. Plan delivery efficiency generally improved with larger margins (p<0.001); mean monitor unit per centigray of the PD decreased from 3.60 ± 1.30 to 1.56 ± 0.13. Conclusion Use of 1 mm MLC margins for dynamic conformal arc-based cranial radiosurgery resulted in optimal tumour control and normal tissue sparing. Clinical significance of these comparative findings warrants further investigation. |
Author | Monaco, D L Tanyi, J A Doss, E J Kubicky, C D Chen, Y Marquez, C M Kato, C M ZMeng, L Fuss, M |
AuthorAffiliation | 4 Macalester College, Saint Paul, MN, USA 2 Department of Nuclear Engineering and Radiation Health Physics, Oregon State University, Corvallis, OR, USA 5 Department of Public Health & Preventive Medicine, Oregon Health and Science University, Portland, OR, USA 1 Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA 3 Department of Internal Medicine, Providence St. Vincent Medical Center, Portland, OR, USA |
AuthorAffiliation_xml | – name: 5 Department of Public Health & Preventive Medicine, Oregon Health and Science University, Portland, OR, USA – name: 3 Department of Internal Medicine, Providence St. Vincent Medical Center, Portland, OR, USA – name: 4 Macalester College, Saint Paul, MN, USA – name: 1 Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA – name: 2 Department of Nuclear Engineering and Radiation Health Physics, Oregon State University, Corvallis, OR, USA |
Author_xml | – sequence: 1 givenname: J A surname: Tanyi fullname: Tanyi, J A email: tanyij@ohsu.edu organization: Department of Radiation Medicine, Oregon Health and Science University, Portland, OR 97239, USA. tanyij@ohsu.edu – sequence: 2 givenname: E J surname: Doss fullname: Doss, E J – sequence: 3 givenname: C M surname: Kato fullname: Kato, C M – sequence: 4 givenname: D L surname: Monaco fullname: Monaco, D L – sequence: 5 givenname: L surname: ZMeng fullname: ZMeng, L – sequence: 6 givenname: Y surname: Chen fullname: Chen, Y – sequence: 7 givenname: C D surname: Kubicky fullname: Kubicky, C D – sequence: 8 givenname: C M surname: Marquez fullname: Marquez, C M – sequence: 9 givenname: M surname: Fuss fullname: Fuss, M |
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Cites_doi | 10.1016/S1042-3680(18)30783-6 10.1118/1.2815356 10.1016/S0360-3016(01)01757-6 10.1016/S0360-3016(01)02585-8 10.1159/000202973 10.1088/0031-9155/47/14/308 10.1159/000416568 10.3109/02841869309093624 10.1118/1.598063 10.1016/S0360-3016(99)00203-5 10.1016/j.ijrobp.2006.01.056 10.1016/S0360-3016(97)00721-9 10.1159/000209293 10.1118/1.595312 10.1118/1.597508 10.1088/0031-9155/52/12/014 10.1016/0360-3016(88)90098-3 10.1118/1.596669 10.1016/0360-3016(91)90171-Y 10.3171/jns.2000.93.supplement_3.0219 10.1016/S0360-3016(03)01563-3 10.1016/S0360-3016(97)00815-8 10.3109/02688698909002808 10.1118/1.1319524 10.1016/j.ijrobp.2009.07.1754 10.1088/0031-9155/49/16/015 |
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References | Bortfeld (2024050213252556600_b3) 2000; 27 Wagner (2024050213252556600_b11) 2003; 57 Grzadziel (2024050213252556600_b8) 2006; 66 Friedman (2024050213252556600_b1) 1990; 1 Das (2024050213252556600_b25) 2008; 35 Galvin (2024050213252556600_b5) 1998; 40 Jin (2024050213252556600_b7) 2007; 52 Nakamura (2024050213252556600_b10) 2001; 51 Rubin (2024050213252556600_b16) 1989; 23 Niemierko (2024050213252556600_b12) 1997; 24 Marks (2024050213252556600_b21) 2010; 76 Mavroidis (2024050213252556600_b13) 2002; 47 Massager (2024050213252556600_b24) 2009; 87 Schultheiss (2024050213252556600_b19) 1983; 10 Biggs (2024050213252556600_b4) 1991; 18 Hitchcock (2024050213252556600_b2) 1989; 3 Cardinale (2024050213252556600_b6) 1999; 45 Massager (2024050213252556600_b22) 2009; 87 Wu (2024050213252556600_b14) 2002; 52 Smith (2024050213252556600_b18) 1998; 40 Lax (2024050213252556600_b23) 1993; 32 Li (2024050213252556600_b27) 1995; 22 Paddick (2024050213252556600_b9) 2000; 93 Goitein (2024050213252556600_b17) 1987 Yin (2024050213252556600_b26) 2004; 49 Emami (2024050213252556600_b15) 1991; 21 Withers (2024050213252556600_b20) 1988; 14 |
References_xml | – volume: 1 start-page: 991 year: 1990 ident: 2024050213252556600_b1 article-title: LINAC radiosurgery. publication-title: Neurosurg Clin N Am doi: 10.1016/S1042-3680(18)30783-6 contributor: fullname: Friedman – volume: 35 start-page: 206 year: 2008 ident: 2024050213252556600_b25 article-title: Small fields: nonequilibrium radiation dosimetry. publication-title: Med Phys doi: 10.1118/1.2815356 contributor: fullname: Das – volume: 51 start-page: 1313 year: 2001 ident: 2024050213252556600_b10 article-title: Dose conformity of gamma knife radiosurgery and risk factors for complications. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)01757-6 contributor: fullname: Nakamura – volume: 52 start-page: 224 year: 2002 ident: 2024050213252556600_b14 article-title: Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(01)02585-8 contributor: fullname: Wu – start-page: 1 year: 1987 ident: 2024050213252556600_b17 article-title: The probability of controlling an inhomogeneously irradiated tumor. publication-title: Report of the working group on the evaluation of treatment planning for particle beam radiotherapy. contributor: fullname: Goitein – volume: 87 start-page: 82 year: 2009 ident: 2024050213252556600_b24 article-title: Experimental analysis of radiation dose distribution in radiosurgery: I. Dose hot spot inside target volume. publication-title: Stereotact Funct Neurosur doi: 10.1159/000202973 contributor: fullname: Massager – volume: 47 start-page: 2471 year: 2002 ident: 2024050213252556600_b13 article-title: Prediction of AVM obliteration after stereotactic radiotherapy using radiobiological modelling. publication-title: Phys Med Biol doi: 10.1088/0031-9155/47/14/308 contributor: fullname: Mavroidis – volume: 23 start-page: 7 year: 1989 ident: 2024050213252556600_b16 article-title: Radiation tolerance of normal tissues. publication-title: Front Radiat Ther Oncol doi: 10.1159/000416568 contributor: fullname: Rubin – volume: 32 start-page: 453 year: 1993 ident: 2024050213252556600_b23 article-title: Target dose versus extra target dose in stereotactic radiosurgery. publication-title: Acta Oncol doi: 10.3109/02841869309093624 contributor: fullname: Lax – volume: 24 start-page: 103 year: 1997 ident: 2024050213252556600_b12 article-title: Reporting and analysing dose distributions: a concept of equivalent uniform dose. publication-title: Med Phys doi: 10.1118/1.598063 contributor: fullname: Niemierko – volume: 45 start-page: 515 year: 1999 ident: 2024050213252556600_b6 article-title: Determining the optimal block margin on the planning target volume for extracranial stereotactic radiotherapy. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(99)00203-5 contributor: fullname: Cardinale – volume: 66 start-page: S87 year: 2006 ident: 2024050213252556600_b8 article-title: Three-dimensional conformal versus intensity-modulated radiotherapy dose planning in stereotactic radiotherapy: application of standard quality parameters for plan evaluation. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2006.01.056 contributor: fullname: Grzadziel – volume: 40 start-page: 507 year: 1998 ident: 2024050213252556600_b18 article-title: Comparison of radiosurgery treatment modalities based on complication and control probabilities. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(97)00721-9 contributor: fullname: Smith – volume: 87 start-page: 137 year: 2009 ident: 2024050213252556600_b22 article-title: Experimental analysis of radiation dose distribution in radiosurgery: II. Dose fall-off outside the target volume. publication-title: Stereotact Funct Neurosurg doi: 10.1159/000209293 contributor: fullname: Massager – volume: 10 start-page: 410 year: 1983 ident: 2024050213252556600_b19 article-title: Models in radiotherapy: volume effects. publication-title: Med Phys doi: 10.1118/1.595312 contributor: fullname: Schultheiss – volume: 22 start-page: 1167 year: 1995 ident: 2024050213252556600_b27 article-title: Lateral electron equilibrium and electron contamination in measurements of head-scatter factors using miniphantoms and brass caps. publication-title: Med Phys doi: 10.1118/1.597508 contributor: fullname: Li – volume: 52 start-page: 3549 year: 2007 ident: 2024050213252556600_b7 article-title: Investigation of optimal beam margins for stereotactic radiotherapy of lung-cancer using Monte Carlo dose calculations. publication-title: Phys Med Biol doi: 10.1088/0031-9155/52/12/014 contributor: fullname: Jin – volume: 14 start-page: 751 year: 1988 ident: 2024050213252556600_b20 article-title: Treatment volume and tissue tolerance. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(88)90098-3 contributor: fullname: Withers – volume: 18 start-page: 753 year: 1991 ident: 2024050213252556600_b4 article-title: Comparison of the penumbra between focused and non-divergent blocks—implications for multileaf collimators. publication-title: Med Phys doi: 10.1118/1.596669 contributor: fullname: Biggs – volume: 21 start-page: 109 year: 1991 ident: 2024050213252556600_b15 article-title: Tolerance of normal tissue to therapeutic irradiation. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/0360-3016(91)90171-Y contributor: fullname: Emami – volume: 93 start-page: 219 year: 2000 ident: 2024050213252556600_b9 article-title: A simple scoring ratio to index the conformity of radiosurgical treatment plans: technical note. publication-title: J Neurosurg doi: 10.3171/jns.2000.93.supplement_3.0219 contributor: fullname: Paddick – volume: 57 start-page: 1141 year: 2003 ident: 2024050213252556600_b11 article-title: A simple and reliable index for scoring rival stereotactic radiosurgery plans. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(03)01563-3 contributor: fullname: Wagner – volume: 40 start-page: 721 year: 1998 ident: 2024050213252556600_b5 article-title: A comparison of multileaf collimator and alloy-block field shaping. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/S0360-3016(97)00815-8 contributor: fullname: Galvin – volume: 3 start-page: 305 year: 1989 ident: 2024050213252556600_b2 article-title: Stereotactic LINAC radiosurgery. publication-title: Br J Neurosurg doi: 10.3109/02688698909002808 contributor: fullname: Hitchcock – volume: 27 start-page: 2494 year: 2000 ident: 2024050213252556600_b3 article-title: What is the optimum leaf width of a multileaf collimator? publication-title: Med Phys doi: 10.1118/1.1319524 contributor: fullname: Bortfeld – volume: 76 start-page: S10 year: 2010 ident: 2024050213252556600_b21 article-title: Use of normal tissue complication probability models in the clinic. publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2009.07.1754 contributor: fullname: Marks – volume: 49 start-page: 3691 year: 2004 ident: 2024050213252556600_b26 article-title: Response corrections for solid-state detectors in megavoltage photon dosimetry. publication-title: Phys Med Biol doi: 10.1088/0031-9155/49/16/015 contributor: fullname: Yin |
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Snippet | The effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was assessed.... Objective The effect of multileaf collimator (MLC) margin on target and normal tissue dose–volume metrics for intracranial stereotactic radiosurgery (SRS) was... OBJECTIVEThe effect of multileaf collimator (MLC) margin on target and normal tissue dose-volume metrics for intracranial stereotactic radiosurgery (SRS) was... |
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SubjectTerms | Brain - surgery Brain Neoplasms - surgery Humans Radiosurgery - methods Radiotherapy Dosage Radiotherapy, Conformal - methods Treatment Outcome |
Title | Dynamic conformal arc cranial stereotactic radiosurgery: implications of multileaf collimator margin on dose-volume metrics |
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