Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies

Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, inclu...

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Published inInternational journal of molecular sciences Vol. 21; no. 18; p. 6765
Main Authors Odegaard, Katherine E., Chand, Subhash, Wheeler, Sydney, Tiwari, Sneham, Flores, Adrian, Hernandez, Jordan, Savine, Mason, Gowen, Austin, Pendyala, Gurudutt, Yelamanchili, Sowmya V.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 15.09.2020
Subjects
Animals
Extracellular Vesicles - metabolism
HIV Infections - metabolism
Humans
Nervous System Diseases - metabolism
Review
Substance-Related Disorders - metabolism
alcohol
drugs of abuse
nicotine
CNS disease
HIV
microRNA (miRNA)
cocaine
methamphetamine (METH)
extracellular vesicles (EV)
opioids
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Abstract Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.
AbstractList Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.
Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the body. As important carriers of various types of cargo, including proteins, lipids, DNA fragments, and a variety of small noncoding RNAs, including miRNAs, mRNAs, and siRNAs, EVs may play an important role in the development of addiction and other neurological pathologies, particularly those related to HIV. In this review, we summarize the findings of EV studies in the context of methamphetamine (METH), cocaine, nicotine, opioid, and alcohol use disorders, highlighting important EV cargoes that may contribute to addiction. Additionally, as HIV and substance abuse are often comorbid, we discuss the potential role of EVs in the intersection of substance abuse and HIV. Taken together, the studies presented in this comprehensive review shed light on the potential role of EVs in the exacerbation of substance use and HIV. As a subject of growing interest, EVs may continue to provide information about mechanisms and pathogenesis in substance use disorders and CNS pathologies, perhaps allowing for exploration into potential therapeutic options.
Author Tiwari, Sneham
Hernandez, Jordan
Wheeler, Sydney
Savine, Mason
Odegaard, Katherine E.
Flores, Adrian
Gowen, Austin
Chand, Subhash
Pendyala, Gurudutt
Yelamanchili, Sowmya V.
AuthorAffiliation Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA; katherine.odegaard@unmc.edu (K.E.O.); subhash.chand@unmc.edu (S.C.); sydney.wheeler@unmc.edu (S.W.); sam.tiwari@unmc.edu (S.T.); a.flores@unmc.edu (A.F.); jordan.hernandez@unmc.edu (J.H.); mason.savine@unmc.edu (M.S.); austin.gowen@unmc.edu (A.G.); gpendyala@unmc.edu (G.P.)
AuthorAffiliation_xml – name: Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE 68198, USA; katherine.odegaard@unmc.edu (K.E.O.); subhash.chand@unmc.edu (S.C.); sydney.wheeler@unmc.edu (S.W.); sam.tiwari@unmc.edu (S.T.); a.flores@unmc.edu (A.F.); jordan.hernandez@unmc.edu (J.H.); mason.savine@unmc.edu (M.S.); austin.gowen@unmc.edu (A.G.); gpendyala@unmc.edu (G.P.)
Author_xml – sequence: 1
  givenname: Katherine E.
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  surname: Odegaard
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  surname: Yelamanchili
  fullname: Yelamanchili, Sowmya V.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32942668$$D View this record in MEDLINE/PubMed
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Issue 18
Keywords alcohol
drugs of abuse
nicotine
CNS disease
HIV
microRNA (miRNA)
cocaine
methamphetamine (METH)
extracellular vesicles (EV)
opioids
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Snippet Extracellular vesicles (EVs) are a broad, heterogeneous class of membranous lipid-bilayer vesicles that facilitate intercellular communication throughout the...
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StartPage 6765
SubjectTerms Animals
Extracellular Vesicles - metabolism
HIV Infections - metabolism
Humans
Nervous System Diseases - metabolism
Review
Substance-Related Disorders - metabolism
Title Role of Extracellular Vesicles in Substance Abuse and HIV-Related Neurological Pathologies
URI https://www.ncbi.nlm.nih.gov/pubmed/32942668
https://www.proquest.com/docview/2444386253
https://pubmed.ncbi.nlm.nih.gov/PMC7554956
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