A Kinase and a Glycosylase Catabolize Pseudouridine in the Peroxisome to Prevent Toxic Pseudouridine Monophosphate Accumulation

• Published in: The Plant cell Vol. 32; no. 3; pp. 722 - 739
• Main Authors: Chen, Mingjia, Witte, Claus-Peter
• Format: Journal Article
• Language: English
• Published: England American Society of Plant Biologists 01.03.2020
• Subjects: Amino Acid Sequence; DNA Glycosylases - chemistry; DNA Glycosylases - metabolism; Escherichia coli - metabolism; Gene Expression Regulation, Plant; Germination; Kinetics; Membrane Potential, Mitochondrial; Metabolome; Models, Biological; Peroxisomes - metabolism; Plant Roots - growth & development; Plant Roots - metabolism; Protein Kinases - chemistry; Protein Kinases - metabolism; Pseudouridine - metabolism; RNA, Plant - metabolism; Seedlings - metabolism; Seeds - growth & development

Pseudouridine (Ψ) is a frequent nucleoside modification that occurs in both noncoding RNAs and mRNAs. In pseudouridine, C5 of uracil is attached to the Rib via an unusual C-glycosidic bond. This RNA modification is introduced on the RNA by site-specific transglycosylation of uridine (U), a process m...