Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 105; no. 7; pp. e2398 - e2407
• Main Authors: Fussey, Jonathan Mark, Beaumont, Robin N, Wood, Andrew R, Vaidya, Bijay, Smith, Joel, Tyrrell, Jessica
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.07.2020
• Subjects: Adiposity - genetics; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Female; Genetic Predisposition to Disease; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Obesity - epidemiology; Obesity - genetics; Online Only; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - genetics; molecular epidemiology; diabetes mellitus; type 2; thyroid neoplasms; mendelian randomization; obesity

Abstract Background The incidence of thyroid cancer is rising, and relatively little is known about modifiable risk factors for the condition. Observational studies have suggested a link between adiposity and thyroid cancer; however, these are subject to confounding and reverse causality. Here, we u...