The association of thrombosis with thrombocytopenia syndrome with cerebral venous thrombosis
[...]according to data reported by Janssen, eight cases of CVT or thrombosis with thrombocytopenia have been associated with the Ad26Cov2.S vaccine [4]. [...]from the studies discussed, all patients had positive PF-4 assays (if the assay was available). [...]as this is a rapidly evolving field, invo...
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| Published in | The American journal of emergency medicine Vol. 53; pp. 269 - 270 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.03.2022
Elsevier Limited |
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| Abstract | [...]according to data reported by Janssen, eight cases of CVT or thrombosis with thrombocytopenia have been associated with the Ad26Cov2.S vaccine [4]. [...]from the studies discussed, all patients had positive PF-4 assays (if the assay was available). [...]as this is a rapidly evolving field, involvement of a multidisciplinary team is recommended to manage a patient with TTS, including hematology, and as discussed in our paper, neurology, neurosurgery, or interventional radiology depending on local practice.Acknowledgements AT, BL, KRS, and AK conceived the idea for this manuscript and contributed substantially to the writing and editing of the review. |
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| AbstractList | [...]according to data reported by Janssen, eight cases of CVT or thrombosis with thrombocytopenia have been associated with the Ad26Cov2.S vaccine [4]. [...]from the studies discussed, all patients had positive PF-4 assays (if the assay was available). [...]as this is a rapidly evolving field, involvement of a multidisciplinary team is recommended to manage a patient with TTS, including hematology, and as discussed in our paper, neurology, neurosurgery, or interventional radiology depending on local practice.Acknowledgements AT, BL, KRS, and AK conceived the idea for this manuscript and contributed substantially to the writing and editing of the review. |
| Author | Spadaro, Anthony Koyfman, Alex Scott, Kevin R. Long, Brit |
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| Keywords | TTS Vaccine-induced thrombosis and thrombocytopenia thrombosis with thrombocytopenia syndrome VITT Thrombosis Cerebral venous thrombosis |
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| References | Janssen Pharmaceuticals Companies of Johnson & Johnson. “Overview of Safety with Janssen's COVID-19 Vaccine (AdCov2.S)”. 4/14/21. Advisory Committee on Immunization Practices (ACIP). Torjesen (bb0025) 2021 Apr 16; 373 Schultz, Sørvoll, Michelsen, Munthe, Lund-Johansen, Ahlen (bb0015) 2021 Apr 9 Spadaro, Scott, Koyfman, Long (bb0005) 2021 Mar 16; 47 American Society of Hematology. Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions. Published April 19, 2021Available at Accessed April 21, 2021. Greinacher, Thiele, Warkentin, Weisser, Kyrle, Eichinger (bb0010) 2021 Apr 9 Schultz (10.1016/j.ajem.2021.04.074_bb0015) 2021 10.1016/j.ajem.2021.04.074_bb0020 10.1016/j.ajem.2021.04.074_bb0030 Greinacher (10.1016/j.ajem.2021.04.074_bb0010) 2021 Spadaro (10.1016/j.ajem.2021.04.074_bb0005) 2021; 47 Torjesen (10.1016/j.ajem.2021.04.074_bb0025) 2021; 373 |
| References_xml | – volume: 373 start-page: n1005 year: 2021 Apr 16 ident: bb0025 article-title: Covid-19: risk of cerebral blood clots from disease is 10 times that from vaccination, study finds publication-title: BMJ. contributor: fullname: Torjesen – volume: 47 start-page: 24 year: 2021 Mar 16 end-page: 29 ident: bb0005 article-title: Cerebral venous thrombosis: diagnosis and management in the emergency department setting publication-title: Am J Emerg Med contributor: fullname: Long – year: 2021 Apr 9 ident: bb0010 article-title: Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination publication-title: N Engl J Med contributor: fullname: Eichinger – year: 2021 Apr 9 ident: bb0015 article-title: Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination publication-title: N Engl J Med contributor: fullname: Ahlen – volume: 373 start-page: n1005 year: 2021 ident: 10.1016/j.ajem.2021.04.074_bb0025 article-title: Covid-19: risk of cerebral blood clots from disease is 10 times that from vaccination, study finds publication-title: BMJ. doi: 10.1136/bmj.n1005 contributor: fullname: Torjesen – year: 2021 ident: 10.1016/j.ajem.2021.04.074_bb0010 article-title: Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination publication-title: N Engl J Med doi: 10.1056/NEJMoa2104840 contributor: fullname: Greinacher – year: 2021 ident: 10.1016/j.ajem.2021.04.074_bb0015 article-title: Thrombosis and thrombocytopenia after ChAdOx1 nCoV-19 vaccination publication-title: N Engl J Med doi: 10.1056/NEJMoa2104882 contributor: fullname: Schultz – ident: 10.1016/j.ajem.2021.04.074_bb0030 – ident: 10.1016/j.ajem.2021.04.074_bb0020 – volume: 47 start-page: 24 year: 2021 ident: 10.1016/j.ajem.2021.04.074_bb0005 article-title: Cerebral venous thrombosis: diagnosis and management in the emergency department setting publication-title: Am J Emerg Med doi: 10.1016/j.ajem.2021.03.040 contributor: fullname: Spadaro |
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| SubjectTerms | Adenoviruses Cerebral venous thrombosis Coronaviruses COVID-19 vaccines Emergency medical care Hematology Humans Immunization Intracranial Thrombosis - complications Intracranial Thrombosis - diagnostic imaging Leukopenia Neurosurgery Patients Pulmonary embolisms Radiology Thrombocytopenia Thrombocytopenia - complications Thromboembolism Thrombosis thrombosis with thrombocytopenia syndrome TTS Vaccine-induced thrombosis and thrombocytopenia Veins & arteries Venous Thrombosis - complications Venous Thrombosis - diagnostic imaging VITT |
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| Title | The association of thrombosis with thrombocytopenia syndrome with cerebral venous thrombosis |
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