Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

• Published in: The Journal of experimental medicine Vol. 218; no. 3
• Main Authors: Rodrigues, Tamara S., de Sá, Keyla S.G., Ishimoto, Adriene Y., Becerra, Amanda, Oliveira, Samuel, Almeida, Leticia, Gonçalves, Augusto V., Perucello, Debora B., Andrade, Warrison A., Castro, Ricardo, Veras, Flavio P., Toller-Kawahisa, Juliana E., Nascimento, Daniele C., de Lima, Mikhael H.F., Silva, Camila M.S., Caetite, Diego B., Martins, Ronaldo B., Castro, Italo A., Pontelli, Marjorie C., de Barros, Fabio C., do Amaral, Natália B., Giannini, Marcela C., Bonjorno, Letícia P., Lopes, Maria Isabel F., Santana, Rodrigo C., Vilar, Fernando C., Auxiliadora-Martins, Maria, Luppino-Assad, Rodrigo, de Almeida, Sergio C.L., de Oliveira, Fabiola R., Batah, Sabrina S., Siyuan, Li, Benatti, Maira N., Cunha, Thiago M., Alves-Filho, José C., Cunha, Fernando Q., Cunha, Larissa D., Frantz, Fabiani G., Kohlsdorf, Tiana, Fabro, Alexandre T., Arruda, Eurico, de Oliveira, Renê D.R., Louzada-Junior, Paulo, Zamboni, Dario S.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.03.2021
• Subjects: Apoptosis; Brief Definitive Report; Comorbidity; COVID-19 - pathology; COVID-19 - virology; Cytokines - biosynthesis; Humans; Infectious Disease and Host Defense; Inflammasomes - metabolism; Innate Immunity and Inflammation; Lung - pathology; Monocytes - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Postmortem Changes; SARS-CoV-2 - physiology; Severity of Illness Index; Treatment Outcome

Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Cas...