Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1

Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and...

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Published inThe Journal of experimental medicine Vol. 216; no. 12; pp. 2689 - 2700
Main Authors Moeller, Jesper B, Leonardi, Irina, Schlosser, Anders, Flamar, Anne-Laure, Bessman, Nicholas J, Putzel, Gregory Garbès, Thomsen, Theresa, Hammond, Mark, Jepsen, Christine S, Skjødt, Karsten, Füchtbauer, Ernst-Martin, Farber, Donna L, Sorensen, Grith L, Iliev, Iliyan D, Holmskov, Uffe, Artis, David
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 02.12.2019
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Abstract Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
AbstractList Host–microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host–mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation. Host–microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host–mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
Author Jepsen, Christine S
Iliev, Iliyan D
Hammond, Mark
Flamar, Anne-Laure
Bessman, Nicholas J
Thomsen, Theresa
Füchtbauer, Ernst-Martin
Putzel, Gregory Garbès
Leonardi, Irina
Schlosser, Anders
Moeller, Jesper B
Skjødt, Karsten
Holmskov, Uffe
Artis, David
Sorensen, Grith L
Farber, Donna L
AuthorAffiliation 1 Jill Roberts Institute for Research in Inflammatory Bowel Disease, Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY
3 Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
4 Columbia Center for Translational Immunology, Department of Surgery and Department of Microbiology and Immunology, Columbia University, New York, NY
2 Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
AuthorAffiliation_xml – name: 1 Jill Roberts Institute for Research in Inflammatory Bowel Disease, Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY
– name: 3 Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
– name: 2 Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark
– name: 4 Columbia Center for Translational Immunology, Department of Surgery and Department of Microbiology and Immunology, Columbia University, New York, NY
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  surname: Iliev
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  email: dartis@med.cornell.edu
  organization: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Friedman Center for Nutrition and Inflammation, Joan and Sanford I. Weill Department of Medicine, Department of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, New York, NY dartis@med.cornell.edu
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DocumentTitleAlternate Chitin-binding receptor FIBCD1 modulates commensal fungi and influences intestinal inflammation
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U. Holmskov and D. Artis contributed equally to this paper.
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Snippet Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities...
Host–microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities...
In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding...
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Title Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1
URI https://www.ncbi.nlm.nih.gov/pubmed/31601676
https://search.proquest.com/docview/2305048082
https://pubmed.ncbi.nlm.nih.gov/PMC6888979
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