Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition - Chang, Cheng; Fonseca, Kari R.; Li, Cheryl; Horner, Weldon; Zawadzke, Laura E.; Salafia, Michelle A.; Welch, Kathryn A.; Strick, Christine A.; Campbell, Brian M.; Gernhardt, Steve S.; Rong, Haojing; Sawant-Basak, Aarti; et al. (Molecular pharmacology, 2018)
Keywords: Animals; Brain - metabolism; Brain Chemistry - drug effects; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - pharmacology; Female; Half-Life; Humans; Kynurenic Acid - analysis; Macaca fascicularis; Male; Pyrazoles - administration & dosage; Pyrazoles - pharmacology; Rats; Tandem Mass Spectrometry; Transaminases - antagonists & inhibitors; Transaminases - metabolism; KYNA; DMSO; IVIVC; CI; PKPD; LC-MS/MS; KAT II; PD; PLP; CSF; NHP; l-KYN; NMDA; IACUC; HBSS; PK; HPLC; KAT