Histones Differentially Modulate the Anticoagulant and Profibrinolytic Activities of Heparin, Heparin Derivatives, and Dabigatran

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 356; no. 2; pp. 305 - 313
• Main Authors: Ammollo, Concetta Tiziana, Semeraro, Nicola, Carratù, Maria Rosaria, Colucci, Mario, Semeraro, Fabrizio
• Format: Journal Article
• Language: English
• Published: United States 01.02.2016
• Subjects: Animals; Anticoagulants - metabolism; Anticoagulants - pharmacology; Bothrops; Cattle; Dabigatran - metabolism; Dabigatran - pharmacology; Dose-Response Relationship, Drug; Factor Xa - metabolism; Female; Fibrinolytic Agents - metabolism; Fibrinolytic Agents - pharmacology; Heparin - metabolism; Heparin - pharmacology; Histones - metabolism; Histones - pharmacology; Humans; Male; Thrombin - antagonists & inhibitors; Thrombin - metabolism

The antithrombin activity of unfractionated heparin (UFH) is offset by extracellular histones, which, along with DNA, represent a novel mediator of thrombosis and a structural component of thrombi. Here, we systematically evaluated the effect of histones, DNA, and histone-DNA complexes on the antico...