Soft tissue small avascular tumor imaging with x-ray phase-contrast micro-CT in-line holography

To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 mum) and various distributions of the pro...

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Published inProceedings of SPIE, the international society for optical engineering Vol. 6913; p. 69133z
Main Authors Nesterets, Yakov, Gureyev, Tim, Stevenson, Andrew, Pogany, Andrew, Wilkins, Steve, Kincaid, Russell, Ye, Hongwei, Vogelsang, Levon, Lipson, Edward, Coman, Ioana, Fourmaux, Sylvain, Kieffer, Jean-Claude, Krol, Andrzej
Format Journal Article
LanguageEnglish
Published United States 01.01.2008
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Summary:To assess the feasibility of small soft tissue avascular tumor micro-CT imaging with x-ray phase-contrast in-line holography, we have studied micro-CT imaging with in-line geometry of small spheroidal avascular tumor models with quiescent cell core (< 250 mum) and various distributions of the proliferating cell density (PCD) forming the outer shell. We have simulated imaging with an ultrafast laser-based x-ray source with a Mo target. We observe phase-contrast enhancement of the tumor boundaries in the reconstructed transaxial images, resulting in improved detection of small soft tissue tumors, providing that the PCD density gradient is sufficiently large.
ISSN:0277-786X
DOI:10.1117/12.772761