Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects

• Published in: Drug metabolism and disposition Vol. 51; no. 8; pp. 995 - 1004
• Main Authors: Lindmark, Bo, Li, Xue-Qing, Bhattacharya, Chandrali, Housler, Greggory, Heijer, Maria, Bragg, Ryan A., Gränfors, Malin, Pelay-Gimeno, Marta, Vaes, Wouter H.J., Menakuru, Somasekhara, Pizzato, Patricia Ely, Ericsson, Hans, Johansson, Susanne
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2023
• Subjects: Administration, Intravenous; Administration, Oral; Biological Availability; Body Fluids; Healthy Volunteers; Humans; Male; OAT; F; CLR; SLC; AUC; HRMS; OCT2; P450; LSC; BCRP; fabs; P-gp; ADME; MR; MATE; MS; AMS; ICH; NCE; Papp; RAD; UPLC; LC; Tmax; PK

An absorption, distribution, metabolism, and excretion study was performed to determine the basic pharmacokinetic parameters, mass balance, and metabolite profiles of balcinrenone, a mineralocorticoid receptor modulator, in humans. This open-label, single-center, nonrandomized study had a two-period...