Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine

• Published in: Drug metabolism and disposition Vol. 48; no. 5; pp. 378 - 385
• Main Authors: Veeravalli, Sunil, Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa, Everett, Jeremy R., Shephard, Elizabeth A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: Animals; Biocatalysis; Female; Male; Mice; Mice, Knockout; NAD - metabolism; NADP - metabolism; Oxygenases - genetics; Oxygenases - metabolism; Proton Magnetic Resonance Spectroscopy; Taurine - analogs & derivatives; Taurine - biosynthesis; Taurine - metabolism; HMBC heteronuclear multiple bond correlation spectroscopy HSQC; TSP; 1D; ca circa FMO
• ISSN: 0090-9556; 1521-009X; 1521-009X
• DOI: 10.1124/dmd.119.089995

Taurine is one of the most abundant amino acids in mammalian tissues. It is obtained from the diet and by de novo synthesis from cysteic acid or hypotaurine. Despite the discovery in 1954 that the oxygenation of hypotaurine produces taurine, the identification of an enzyme catalyzing this reaction h...