Neurotransmitter Modulation of Carotid Body Germinal Niche

• Published in: International journal of molecular sciences Vol. 21; no. 21; p. 8231
• Main Authors: Sobrino, Verónica, Platero-Luengo, Aida, Annese, Valentina, Navarro-Guerrero, Elena, González-Rodríguez, Patricia, López-Barneo, José, Pardal, Ricardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 03.11.2020
• Subjects: Adaptation, Physiological - physiology; Animals; Carotid Body - cytology; Cell Differentiation - physiology; Humans; Hypoxia - metabolism; Hypoxia - physiopathology; Neurogenesis - physiology; Neurons - physiology; Neurotransmitter Agents - metabolism; Neurotransmitter Agents - physiology; Oxygen - metabolism; Review; Stem Cell Niche - physiology; hypoxia; maturation; differentiation; germinal niche; proliferation; angiogenesis; glomus cells; neurotransmitters; neurogenesis; carotid body; mesenchymal progenitors; neuroblasts

The carotid body (CB), a neural-crest-derived organ and the main arterial chemoreceptor in mammals, is composed of clusters of cells called glomeruli. Each glomerulus contains neuron-like, O2-sensing glomus cells, which are innervated by sensory fibers of the petrosal ganglion and are located in clo...