Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury
Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can prote...
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Published in | Biochemical and biophysical research communications Vol. 500; no. 2; pp. 310 - 317 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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United States
Elsevier Inc
02.06.2018
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Abstract | Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization.
To investigate the effects of exosomes in the I/R injury of flap transplantation in vivo, flaps were subjected to 6 h of ischemia by ligating the left superficial inferior epigastric vessels (SIEA) followed by blood perfusion. Exosomes derived from normal ADSC (ADSC-exos) and exosomes derived from ADSC preconditioned with H2O2 (H2O2-ADSC-exos) were injected into the flaps. Then, the blood perfusion unit (BPU) of the flaps was measured by Laser Doppler Perfusion Imaging (LDPI) and microvessel density was determined by the endothelial with cell marker CD31 with Immunohistochemistry (IHC) staining. Inflammatory cell infiltration of the skin flap and apoptosis were detected by hematoxylin & eosin staining (H&E) and the TdT-mediated biotinylated dUTP nick end-labeling (TUNEL) technique.
In vivo, exosomes significantly increased flap survival and capillary density compared to I/R on postoperative day 5, and decreased the inflammatory reaction and apoptosis in the skin flap (P < 0.05). Furthermore, H2O2-ADSC-exos had better outcomes compared to normal exosomes (P < 0.05). ADSC-exos could significantly increase human umbilical vein endothelial cell (HUVEC) proliferation (P < 0.05), but no statistic difference was found in exosomes derived from different microenvironments (P > 0.05). HUVEC co-cultured with H2O2-ADSC-exos increased the migration ratio and generated more cord-like structures compared to ADSC-exos and the control group (P < 0.05).
ADSC-exos can enhance skin flap survival, promote neovascularization and alleviate the inflammation reaction and apoptosis in the skin flap after I/R injury. The use of a specific microenvironment for in vitro stem cell culture, such as one containing a low concentration of H2O2, will facilitate the development of customized exosomes for cell-free therapeutic applications in skin flap transplantation.
•Exosomes derived from ADSCs (ADSC-exos) served as a novel therapeutic alternative for a skin flap.•ADSC-exos treatment is effective for enhancing skin flap recovery and angiogenesis following I/R injury.•ADSC-exos treatment significantly reduced inflammation and apoptosis in the skin flap in I/R injury.•Exosomes derived from ADSCs stimulated by low concentration of H2O2 have better effects in skin flap recovery.•Low concentrations of H2O2 stimulation may serve as a promising pretreatment for exosome-based skin flap survival. |
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AbstractList | BACKGROUNDMesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization.METHODSTo investigate the effects of exosomes in the I/R injury of flap transplantation in vivo, flaps were subjected to 6 h of ischemia by ligating the left superficial inferior epigastric vessels (SIEA) followed by blood perfusion. Exosomes derived from normal ADSC (ADSC-exos) and exosomes derived from ADSC preconditioned with H2O2 (H2O2-ADSC-exos) were injected into the flaps. Then, the blood perfusion unit (BPU) of the flaps was measured by Laser Doppler Perfusion Imaging (LDPI) and microvessel density was determined by the endothelial with cell marker CD31 with Immunohistochemistry (IHC) staining. Inflammatory cell infiltration of the skin flap and apoptosis were detected by hematoxylin & eosin staining (H&E) and the TdT-mediated biotinylated dUTP nick end-labeling (TUNEL) technique.RESULTSIn vivo, exosomes significantly increased flap survival and capillary density compared to I/R on postoperative day 5, and decreased the inflammatory reaction and apoptosis in the skin flap (P < 0.05). Furthermore, H2O2-ADSC-exos had better outcomes compared to normal exosomes (P < 0.05). ADSC-exos could significantly increase human umbilical vein endothelial cell (HUVEC) proliferation (P < 0.05), but no statistic difference was found in exosomes derived from different microenvironments (P > 0.05). HUVEC co-cultured with H2O2-ADSC-exos increased the migration ratio and generated more cord-like structures compared to ADSC-exos and the control group (P < 0.05).CONCLUSIONADSC-exos can enhance skin flap survival, promote neovascularization and alleviate the inflammation reaction and apoptosis in the skin flap after I/R injury. The use of a specific microenvironment for in vitro stem cell culture, such as one containing a low concentration of H2O2, will facilitate the development of customized exosomes for cell-free therapeutic applications in skin flap transplantation. Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization. To investigate the effects of exosomes in the I/R injury of flap transplantation in vivo, flaps were subjected to 6 h of ischemia by ligating the left superficial inferior epigastric vessels (SIEA) followed by blood perfusion. Exosomes derived from normal ADSC (ADSC-exos) and exosomes derived from ADSC preconditioned with H O (H O -ADSC-exos) were injected into the flaps. Then, the blood perfusion unit (BPU) of the flaps was measured by Laser Doppler Perfusion Imaging (LDPI) and microvessel density was determined by the endothelial with cell marker CD31 with Immunohistochemistry (IHC) staining. Inflammatory cell infiltration of the skin flap and apoptosis were detected by hematoxylin & eosin staining (H&E) and the TdT-mediated biotinylated dUTP nick end-labeling (TUNEL) technique. In vivo, exosomes significantly increased flap survival and capillary density compared to I/R on postoperative day 5, and decreased the inflammatory reaction and apoptosis in the skin flap (P < 0.05). Furthermore, H O -ADSC-exos had better outcomes compared to normal exosomes (P < 0.05). ADSC-exos could significantly increase human umbilical vein endothelial cell (HUVEC) proliferation (P < 0.05), but no statistic difference was found in exosomes derived from different microenvironments (P > 0.05). HUVEC co-cultured with H O -ADSC-exos increased the migration ratio and generated more cord-like structures compared to ADSC-exos and the control group (P < 0.05). ADSC-exos can enhance skin flap survival, promote neovascularization and alleviate the inflammation reaction and apoptosis in the skin flap after I/R injury. The use of a specific microenvironment for in vitro stem cell culture, such as one containing a low concentration of H O , will facilitate the development of customized exosomes for cell-free therapeutic applications in skin flap transplantation. Highlights: • Exosomes derived from ADSCs (ADSC-exos) served as a novel therapeutic alternative for a skin flap. • ADSC-exos treatment is effective for enhancing skin flap recovery and angiogenesis following I/R injury. • ADSC-exos treatment significantly reduced inflammation and apoptosis in the skin flap in I/R injury. • Exosomes derived from ADSCs stimulated by low concentration of H{sub 2}O{sub 2} have better effects in skin flap recovery. • Low concentrations of H{sub 2}O{sub 2} stimulation may serve as a promising pretreatment for exosome-based skin flap survival. Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization. Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative treatment for cell therapy. This aim of the study was to evaluate whether exosomes derived from adipose mesenchymal stem cell (ADSC) can protect the skin flap during ischemia-reperfusion (I/R) injury and induce neovascularization. To investigate the effects of exosomes in the I/R injury of flap transplantation in vivo, flaps were subjected to 6 h of ischemia by ligating the left superficial inferior epigastric vessels (SIEA) followed by blood perfusion. Exosomes derived from normal ADSC (ADSC-exos) and exosomes derived from ADSC preconditioned with H2O2 (H2O2-ADSC-exos) were injected into the flaps. Then, the blood perfusion unit (BPU) of the flaps was measured by Laser Doppler Perfusion Imaging (LDPI) and microvessel density was determined by the endothelial with cell marker CD31 with Immunohistochemistry (IHC) staining. Inflammatory cell infiltration of the skin flap and apoptosis were detected by hematoxylin & eosin staining (H&E) and the TdT-mediated biotinylated dUTP nick end-labeling (TUNEL) technique. In vivo, exosomes significantly increased flap survival and capillary density compared to I/R on postoperative day 5, and decreased the inflammatory reaction and apoptosis in the skin flap (P < 0.05). Furthermore, H2O2-ADSC-exos had better outcomes compared to normal exosomes (P < 0.05). ADSC-exos could significantly increase human umbilical vein endothelial cell (HUVEC) proliferation (P < 0.05), but no statistic difference was found in exosomes derived from different microenvironments (P > 0.05). HUVEC co-cultured with H2O2-ADSC-exos increased the migration ratio and generated more cord-like structures compared to ADSC-exos and the control group (P < 0.05). ADSC-exos can enhance skin flap survival, promote neovascularization and alleviate the inflammation reaction and apoptosis in the skin flap after I/R injury. The use of a specific microenvironment for in vitro stem cell culture, such as one containing a low concentration of H2O2, will facilitate the development of customized exosomes for cell-free therapeutic applications in skin flap transplantation. •Exosomes derived from ADSCs (ADSC-exos) served as a novel therapeutic alternative for a skin flap.•ADSC-exos treatment is effective for enhancing skin flap recovery and angiogenesis following I/R injury.•ADSC-exos treatment significantly reduced inflammation and apoptosis in the skin flap in I/R injury.•Exosomes derived from ADSCs stimulated by low concentration of H2O2 have better effects in skin flap recovery.•Low concentrations of H2O2 stimulation may serve as a promising pretreatment for exosome-based skin flap survival. |
Author | Yan, Xin-long Li, Xiao-dong Pei, Xue-tao Bai, Yun Zeng, Quan Ren, Jing Han, Yu-di Han, Yan |
Author_xml | – sequence: 1 givenname: Yun surname: Bai fullname: Bai, Yun organization: Nankai University School of Medicine, Tianjin, PR China – sequence: 2 givenname: Yu-di surname: Han fullname: Han, Yu-di organization: Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing 100853, PR China – sequence: 3 givenname: Xin-long surname: Yan fullname: Yan, Xin-long organization: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing 100850, PR China – sequence: 4 givenname: Jing surname: Ren fullname: Ren, Jing organization: Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing 100853, PR China – sequence: 5 givenname: Quan surname: Zeng fullname: Zeng, Quan organization: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing 100850, PR China – sequence: 6 givenname: Xiao-dong surname: Li fullname: Li, Xiao-dong organization: Medical School of Chinese PLA, Beijing 100853, PR China – sequence: 7 givenname: Xue-tao surname: Pei fullname: Pei, Xue-tao email: peixt@nic.bmi.ac.cn organization: Stem Cell and Regenerative Medicine Lab, Beijing Institute of Transfusion Medicine, Beijing 100850, PR China – sequence: 8 givenname: Yan surname: Han fullname: Han, Yan email: 13720086335@163.com organization: Department of Plastic and Reconstructive Surgery, PLA General Hospital, Beijing 100853, PR China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29654765$$D View this record in MEDLINE/PubMed https://www.osti.gov/biblio/23125215$$D View this record in Osti.gov |
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Keywords | Skin flap transplantation Ischemia-reperfusion injury Adipose-derived stem cells Hydrogen peroxide Neovascularization Exosomes |
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Snippet | Mesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an alternative... BACKGROUNDMesenchymal stem cell (MSC)-derived exosomes have been recognized as new candidates for the treatment of ischemic disease or injury and may be an... Highlights: • Exosomes derived from ADSCs (ADSC-exos) served as a novel therapeutic alternative for a skin flap. • ADSC-exos treatment is effective for... |
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SubjectTerms | 60 APPLIED LIFE SCIENCES Adipose-derived stem cells ANGIOGENESIS Exosomes Hydrogen peroxide INFLAMMATION ISCHEMIA Ischemia-reperfusion injury Neovascularization SKIN Skin flap transplantation STEM CELLS |
Title | Adipose mesenchymal stem cell-derived exosomes stimulated by hydrogen peroxide enhanced skin flap recovery in ischemia-reperfusion injury |
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