Human Cytomegalovirus Compromises Development of Cerebral Organoids

• Published in: Journal of virology Vol. 93; no. 17
• Main Authors: Brown, Rebecca M., Rana, Pranav S. J. B., Jaeger, Hannah K., O’Dowd, John M., Balemba, Onesmo B., Fortunato, Elizabeth A.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2019
• Subjects: Virus-Cell Interactions; induced pluripotent stem cells; cortical development; neural marker expression; human cytomegalovirus; cerebral organoid

Human cytomegalovirus (HCMV) is a leading cause of central nervous system birth defects, ranging from microcephaly to hearing impairment. Recent literature has provided descriptions of delayed and abnormal maturation of developing cortical tissue in infected clinical specimens. We have found that in...