Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 85; no. 5; pp. 523 - 530
• Main Authors: D’Argenio, Giuseppe, Petrosino, Stefania, Gianfrani, Carmen, Valenti, Marta, Scaglione, Giuseppe, Grandone, Ilenia, Nigam, Santosh, Sorrentini, Italo, Mazzarella, Giuseppe, Di Marzo, Vincenzo
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.05.2007; Springer Nature B.V
• Subjects: 2-Arachidonoylglycerol; Adolescent; Adult; Amides; Anandamide; Animals; Arachidonic Acids - metabolism; Atrophy; Biological and medical sciences; Cannabinoid CB1 receptors; Cannabinoid Receptor Modulators - metabolism; Cannabinoids; Case-Control Studies; Celiac disease; Celiac Disease - chemically induced; Celiac Disease - diet therapy; Celiac Disease - metabolism; Celiac Disease - pathology; Child; Colitis; Diet, Protein-Restricted; Disease Models, Animal; Duodenum - metabolism; Duodenum - pathology; Endocannabinoid system; Endocannabinoids; Ethanolamines; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Gluten; Glycerides - metabolism; Glycerol; Humans; Inflammatory bowel diseases; Intestine; Jejunum; Jejunum - metabolism; Jejunum - pathology; Male; Medical sciences; Methotrexate; Middle Aged; Mucosa; Other diseases. Semiology; Palmitic Acids - metabolism; Palmitoylethanolamide; Patients; Peroxidase; Peroxidase - metabolism; Polyunsaturated Alkamides - metabolism; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 - metabolism; Remission; Remission (Medicine); Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Time Factors; Up-Regulation; Antineoplastic agent; Immunopathology; Rat; Rodentia; Inflammation; Cannabinoid; Coeliac disease; Antifolate; Atrophy; Medicine; Celiac disease; Vertebrata; Mammalia; Endogenous; Treatment; Antimetabolic; Endocannabinoid; Intestinal malabsorption; Animal; Intestinal inflammation; Digestive diseases; Intestinal disease; Methotrexate

The endocannabinoid system is upregulated in both human inflammatory bowel diseases and experimental models of colitis. In this study, we investigated whether this upregulation is a marker also of celiac disease-induced atrophy. The levels of the cannabinoid CB(1) receptor, of the endocannabinoids,...