A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function
Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a c...
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| Published in | Bioorganic & medicinal chemistry letters Vol. 16; no. 3; pp. 718 - 721 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.02.2006
Elsevier |
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| Abstract | Nicotinamide (
2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function.
Nicotinamide (
2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. |
|---|---|
| AbstractList | Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. Nicotinamide ( 2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. |
| Author | Chambers, Robert J. Fisher, Douglas A. Castleberry, Tessa A. Turner, Claudia R. Cheng, John B. Sheils, Alissa L. Nettleton, David O. Lam, Kelvin T. Marfat, Anthony Shirley, John T. Salter, Eben D. Abrams, Kristin Umland, John P. Pillar, Joann D. Kamath, Ajith V. |
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| Keywords | PDE4D Eosinophil Phosphodiesterase Human 3',5'-Cyclic-nucleotide phosphodiesterase Enzyme Nitrogen heterocycle Isozyme Enzyme inhibitor Esterases Selectivity Phosphoric diester hydrolases Chemotaxis In vitro Thiophene derivatives Rolipram Six membered ring Hydrolases Carboxamide Fluorine Organic compounds Mechanism of action Comparative study Release |
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| Snippet | Nicotinamide (
2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis... Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis... |
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| SubjectTerms | 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-AMP Phosphodiesterases - physiology Analytical, structural and metabolic biochemistry Biological and medical sciences Chemotaxis - drug effects Cyclic Nucleotide Phosphodiesterases, Type 4 Enzymes and enzyme inhibitors Eosinophil Eosinophils - drug effects Eosinophils - physiology Fundamental and applied biological sciences. Psychology Hydrolases Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Isoenzymes - metabolism Leukocytes - drug effects Leukocytes - physiology Medical sciences Miscellaneous Niacinamide - antagonists & inhibitors PDE4D Pharmacology. Drug treatments Phosphodiesterase Phosphodiesterase Inhibitors - chemistry Phosphodiesterase Inhibitors - pharmacology Rolipram - chemistry Rolipram - pharmacology |
| Title | A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function |
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