Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration

• Published in: International journal of molecular sciences Vol. 22; no. 6; p. 3218
• Main Authors: Tellman, Tristen V., Cruz, Lissette A., Grindel, Brian J., Farach-Carson, Mary C.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 22.03.2021
• Subjects: Cell Adhesion; Cell Adhesion Molecules - metabolism; Cell Line, Tumor; Cell Movement; Fluorescent Antibody Technique; Humans; Male; Matrix Metalloproteinase 7 - metabolism; Models, Biological; Nerve Tissue Proteins - metabolism; Neuropilin-1 - metabolism; Prostatic Neoplasms - etiology; Prostatic Neoplasms - metabolism; Protein Binding; Proteolysis; migration; perlecan/HSPG2; prostate cancer; dyscohesion; matrilysin/MMP-7; microtumors

The Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex at the cell surface of prostate cancer (PCa) cells influences cell–cell cohesion and dyscohesion. We investigated matrix metalloproteinase-7/matrilysin (MMP-7)’s ability to digest components of the PSPN Complex in bone metastatic PCa c...