Differential Regulation of Ciliary Neurotrophic Factor and Its Receptor in the Rat Hippocampus in Response to Kainic Acid-induced Excitotoxicity
We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose...
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| Published in | Molecules and cells Vol. 17; no. 2; pp. 292 - 296 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
한국분자세포생물학회
30.04.2004
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| ISSN | 1016-8478 0219-1032 |
| DOI | 10.1016/S1016-8478(23)13040-8 |
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| Abstract | We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFRalpha mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h-2 d) increase in CNTFRalpha was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFRalpha are differentially regulated in hippocampal neurons and reactive astrocytes following KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses. |
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| AbstractList | We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFRalpha mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h-2 d) increase in CNTFRalpha was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFRalpha are differentially regulated in hippocampal neurons and reactive astrocytes following KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses. We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFRalpha mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h-2 d) increase in CNTFRalpha was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFRalpha are differentially regulated in hippocampal neurons and reactive astrocytes following KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses.We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following intraperitoneal administration of a convulsant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFRalpha mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h-2 d) increase in CNTFRalpha was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFRalpha are differentially regulated in hippocampal neurons and reactive astrocytes following KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses. We analyzed the changes in expression of ciliary neu-rotrophic factor (CNTF) and its receptor, ligand-binding subunit (CNTFR), in the hippocampus following intraperitoneal administration of a convul-sant dose of kainic acid (KA). Immunohistochemistry and immunoblotting showed that CNTF levels rose dramatically between day 1 and day 10, and that the CNTF was located in reactive astrocytes. In contrast, upregulation of CNTFR mRNA, occurred in neurons as well as astrocytes. A rapid, and short-lived (3 h2 d) increase in CNTFR was also observed in the more resistant granule cells and CA2 pyramidal neurons. The increase in astrocytes was detected by day 1 and was sustained for more than 5 d. These results show that CNTF and CNTFR are differentially regulated in hippocampal neurons and reactive astrocytes fol-lowing KA injection, indicating that these proteins may be involved in the regulation of astrocyte and neuronal degenerative responses. KCI Citation Count: 5 |
| Author | Park, Hyun-Jung Choi, Jeong-Sun Cha, Jung-Ho Lee, Mun-Yong Kim, Seong Yun Choi, Yun-Sik Chung, Jin-Woong Chun, Myung-Hoon |
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| Snippet | We analyzed the changes in expression of ciliary neurotrophic factor (CNTF) and its receptor, ligand-binding subunit a (CNTFRa), in the hippocampus following... We analyzed the changes in expression of ciliary neu-rotrophic factor (CNTF) and its receptor, ligand-binding subunit (CNTFR), in the hippocampus following... |
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| SubjectTerms | Animals Astrocytes - cytology Astrocytes - metabolism Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - metabolism Convulsants - pharmacology Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Agonists - toxicity Gene Expression Regulation Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Kainic Acid - pharmacology Kainic Acid - toxicity Male Neurons - cytology Neurons - metabolism Neurotoxins Protein Subunits - genetics Protein Subunits - metabolism Rats Rats, Sprague-Dawley Receptor, Ciliary Neurotrophic Factor - genetics Receptor, Ciliary Neurotrophic Factor - metabolism Time Factors 생물학 |
| Title | Differential Regulation of Ciliary Neurotrophic Factor and Its Receptor in the Rat Hippocampus in Response to Kainic Acid-induced Excitotoxicity |
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