Identification and Structural Aspects of G-Quadruplex-Forming Sequences from the Influenza A Virus Genome

• Published in: International journal of molecular sciences Vol. 22; no. 11; p. 6031
• Main Authors: Tomaszewska, Maria, Szabat, Marta, Zielińska, Karolina, Kierzek, Ryszard
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 02.06.2021
• Subjects: Computational Biology; G-Quadruplexes; Genome, Viral - drug effects; Genome, Viral - genetics; Humans; Influenza A virus - drug effects; Influenza A virus - genetics; Influenza A Virus, H1N1 Subtype - genetics; Influenza, Human - genetics; Influenza, Human - pathology; RNA, Viral - genetics; Virus Replication - drug effects; Virus Replication - genetics; Influenza A virus; RNA G-quadruplexes; potential quadruplex-forming sequence

Influenza A virus (IAV) causes seasonal epidemics and sporadic pandemics, therefore is an important research subject for scientists around the world. Despite the high variability of its genome, the structure of viral RNA (vRNA) possesses features that remain constant between strains and are biologic...