Fiber-bundle microendoscopy with sub-diffuse reflectance spectroscopy and intensity mapping for multimodal optical biopsy of stratified epithelium

• Published in: Biomedical optics express Vol. 6; no. 12; pp. 4934 - 4950
• Main Authors: Greening, Gage J, James, Haley M, Powless, Amy J, Hutcheson, Joshua A, Dierks, Mary K, Rajaram, Narasimhan, Muldoon, Timothy J
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01.12.2015
• Subjects: (170.6510) Spectroscopy, tissue diagnostics; (060.2310) Fiber optics; (110.2945) Illumination design; (170.2150) Endoscopic imaging; (120.4640) Optical instruments

Early detection of structural or functional changes in dysplastic epithelia may be crucial for improving long-term patient care. Recent work has explored myriad non-invasive or minimally invasive "optical biopsy" techniques for diagnosing early dysplasia, such as high-resolution microendos...