Multiphysics simulations reveal haemodynamic impacts of patient‐derived fibrosis‐related changes in left atrial tissue mechanics

• Published in: The Journal of physiology Vol. 602; no. 24; pp. 6789 - 6812
• Main Authors: Gonzalo, Alejandro, Augustin, Christoph M., Bifulco, Savannah F., Telle, Åshild, Chahine, Yaacoub, Kassar, Ahmad, Guerrero‐Hurtado, Manuel, Durán, Eduardo, Martínez‐Legazpi, Pablo, Flores, Oscar, Bermejo, Javier, Plank, Gernot, Akoum, Nazem, Boyle, Patrick M., Alamo, Juan C.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.12.2024
• Subjects: Atrial Function, Left - physiology; computational fluid dynamics; Computer applications; Computer Simulation; electromechanics; emptying fraction; Fibrosis; Gadolinium; haemodynamics; Heart Atria - diagnostic imaging; Heart Atria - physiopathology; Hemodynamics; Humans; Ischemia; left atrium; Magnetic Resonance Imaging; Models, Cardiovascular; multiphysics; Myopathy; Patients; Simulation; Stroke; thrombosis; thrombosis; computational fluid dynamics; emptying fraction; fibrosis; left atrium; multiphysics; electromechanics; haemodynamics

Stroke is a leading cause of death and disability worldwide. Atrial myopathy, including fibrosis, is associated with an increased risk of ischaemic stroke, but the mechanisms underlying this association are poorly understood. Fibrosis modifies myocardial structure, impairing electrical propagation a...