Keratinocyte growth factor attenuates lung leak induced by alpha-naphthylthiourea in rats

• Published in: Critical care medicine Vol. 24; no. 6; p. 925
• Main Authors: Mason, C M, Guery, B P, Summer, W R, Nelson, S
• Format: Journal Article
• Language: English
• Published: United States 01.06.1996
• Subjects: Animals; Bronchoalveolar Lavage Fluid - chemistry; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances - administration & dosage; Growth Substances - therapeutic use; Organ Size - drug effects; Prospective Studies; Pulmonary Edema - chemically induced; Pulmonary Edema - pathology; Pulmonary Edema - prevention & control; Pulmonary Wedge Pressure; Random Allocation; Rats; Rats, Sprague-Dawley; Rodenticides - antagonists & inhibitors; Thiourea - analogs & derivatives; Thiourea - antagonists & inhibitors

To investigate the effect of pretreatment with keratinocyte growth factor on acute permeability pulmonary edema. Prospective, randomized, controlled animal study. University research laboratory. Specific pathogen-free Sprague-Dawley rats. Acute permeability pulmonary edema was induced with an inject...