Prophylactic Platelet Administration During Massive Transfusion: A Prospective, Randomized, Double-Blind Clinical Study
Prior studies at Harborview Medical Center have suggested that dilutional thrombocytopenia is a major etiology of microvascular, nonmechanical bleeding (MVB). We undertook a prospective randomized double-blind clinical study to compare the prophylactic effects of 6 units of platelet concentrates (PL...
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Published in | Annals of surgery Vol. 203; no. 1; pp. 40 - 48 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hagerstown, MD
Copyright Wolters Kluwer Health, Inc. All rights reserved
01.01.1986
Lippincott |
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Abstract | Prior studies at Harborview Medical Center have suggested that dilutional thrombocytopenia is a major etiology of microvascular, nonmechanical bleeding (MVB). We undertook a prospective randomized double-blind clinical study to compare the prophylactic effects of 6 units of platelet concentrates (PLT) versus 2 units of fresh frozen plasma (FFP) administered with every 12 units of modified whole blood in patients undergoing massive transfusion (12 or more units in 12 hours). After exclusions, three of 17 patients who received PLT and three of 16 patients who received FFP developed MVB, an incidence no different from our previous findings. Regression lines of platelet counts during transfusion were no different between groups, and both groups had higher platelet counts than predicted from a standard washout equation. Only one patient had evidence of dilutional thrombocytopenia as a cause for MVB. Prophylactic platelet administration is not warranted as a routine measure to prevent MVB. |
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AbstractList | Prior studies at Harborview Medical Center have suggested that dilutional thrombocytopenia is a major etiology of microvascular, nonmechanical bleeding (MVB). We undertook a prospective randomized double-blind clinical study to compare the prophylactic effects of 6 units of platelet concentrates (PLT) versus 2 units of fresh frozen plasma (FFP) administered with every 12 units of modified whole blood in patients undergoing massive transfusion (12 or more units in 12 hours). After exclusions, three of 17 patients who received PLT and three of 16 patients who received FFP developed MVB, an incidence no different from our previous findings. Regression lines of platelet counts during transfusion were no different between groups, and both groups had higher platelet counts than predicted from a standard washout equation. Only one patient had evidence of dilutional thrombocytopenia as a cause for MVB. Prophylactic platelet administration is not warranted as a routine measure to prevent MVB. |
Author | CIAVARELLA, DAVID COUNTS, RICHARD B HEIMBACH, DAVID M BARON, LOIS PAVLIN, EDWARD CARRICO, JAMES C REED, LAWRENCE R |
AuthorAffiliation | From the Departments of Surgery, Medicine, and Anesthesiology, Harborview Medical Center, and the Puget Sound Blood Center, Seattle, Washington |
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Keywords | Human Thrombocytopenia Massive transfusion Platelet Transfusion Complication Hemodilution Hemopathy Hemorrhage |
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SubjectTerms | Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Platelets Blood Transfusion Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Clinical Trials as Topic Double-Blind Method Female Hemorrhage - etiology Hemorrhage - prevention & control Humans Male Medical sciences Middle Aged Plasma Platelet Count Prospective Studies Random Allocation Thrombocytopenia - etiology Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy Wounds and Injuries - surgery |
Title | Prophylactic Platelet Administration During Massive Transfusion: A Prospective, Randomized, Double-Blind Clinical Study |
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