Generation of animal form by the Chordin/Tolloid/BMP gradient: 100 years after D'Arcy Thompson

• Published in: Development, growth & differentiation Vol. 59; no. 7; pp. 580 - 592
• Main Authors: De Robertis, Edward M., Moriyama, Yuki, Colozza, Gabriele
• Format: Journal Article
• Language: English
• Published: Japan 01.09.2017
• Subjects: Animals; Bone Morphogenetic Proteins - metabolism; dorsal‐ventral patterning; Embryo, Nonmammalian - cytology; Embryo, Nonmammalian - metabolism; evolution of body form; Glycoproteins - metabolism; Intercellular Signaling Peptides and Proteins - metabolism; Models, Biological; morphogen gradient; morphogenesis; reaction‐diffusion; Signal Transduction - physiology; Tolloid-Like Metalloproteinases - metabolism; Xenopus laevis; evolution of body form; reaction-diffusion; morphogenesis; morphogen gradient; dorsal-ventral patterning

The classic book “On Growth and Form” by naturalist D'Arcy Thompson was published 100 years ago. To celebrate this landmark, we present experiments in the Xenopus embryo that provide a framework for understanding how simple, quantitative transformations of a morphogen gradient might have affect...