Dendritic Cell Vaccine for Recurrent High-Grade Gliomas in Pediatric and Adult Subjects: Clinical Trial Protocol

• Published in: Neurosurgery Vol. 73; no. 5; pp. 863 - 867
• Main Authors: Shah, Ashish H., Bregy, Amade, Heros, Deborah O., Komotar, Ricardo J., Goldberg, John
• Format: Journal Article
• Language: English
• Published: United States Copyright by the Congress of Neurological Surgeons 01.11.2013; Wolters Kluwer Health, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Brain Neoplasms - immunology; Brain Neoplasms - therapy; Cancer Vaccines - therapeutic use; Cohort Studies; Dendritic cells; Dendritic Cells - physiology; Female; Glioma; Glioma - immunology; Glioma - therapy; Humans; Immunotherapy; Magnetic Resonance Imaging; Male; Middle Aged; Neurosurgery; Pediatrics; Transplantation, Autologous; Treatment Outcome; Vaccines; Young Adult

BACKGROUND:Although there have been significant advances in understanding the basic pathogenesis of glioblastoma multiforme, the median survival of patients has changed little in the past 25 years. Recent studies have suggested that immune modulation through dendritic cell (DC) vaccines may stimulat...