Effects of simvastatin, atorvastatin, ezetimibe, and ezetimibe + simvastatin combination on the inflammatory process and on the liver metabolic changes of arthritic rats

• Published in: Fundamental & clinical pharmacology Vol. 26; no. 6; pp. 722 - 734
• Main Authors: Bracht, Lívia, Barbosa, Carmem Patrícia, Caparroz-Assef, Silvana Martins, Cuman, Roberto Kenji Nakamura, Ishii-Iwamoto, Emy Luiza, Bracht, Adelar, Bersani-Amado, Ciomar Aparecida
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Blackwell
• Subjects: adjuvant arthritis; Alanine; Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Anti-Inflammatory Agents - therapeutic use; Arthritis; Arthritis, Experimental - blood; Arthritis, Experimental - drug therapy; Arthritis, Experimental - metabolism; Atorvastatin; Atorvastatin Calcium; Azetidines - administration & dosage; Azetidines - therapeutic use; Biological and medical sciences; Cholesterol; Diseases of the osteoarticular system; Drug Therapy, Combination; Ezetimibe; ezetimibe + simvastatin combination; Freund's adjuvant; Glucose; Heptanoic Acids - administration & dosage; Heptanoic Acids - adverse effects; Heptanoic Acids - therapeutic use; Inflammation; Inflammatory joint diseases; Joint diseases; Kidney; Leukocyte Count; Leukocytes - cytology; Leukocytes - drug effects; Liver; Liver - drug effects; Liver - enzymology; Liver - metabolism; Liver Function Tests; Medical sciences; mineral oil; Mycobacterium tuberculosis; Oxygen; Perfusion; Pharmacology. Drug treatments; Pyrroles - administration & dosage; Pyrroles - adverse effects; Pyrroles - therapeutic use; Rats; Rats, Sprague-Dawley; Simvastatin; Simvastatin - administration & dosage; Simvastatin - adverse effects; Simvastatin - therapeutic use; Spleen; transaminase; Animal model; Rat; Liver; Diseases of the osteoarticular system; Ezetimibe; Autoimmune disease; Inflammatory joint disease; adjuvant arthritis; Hypocholesterolemic agent; HMG-CoA reductase inhibitor; Drug; Immunopathology; Digestive system; Enzyme; Simvastatin; Rodentia; Enzyme inhibitor; Statin derivative; Inflammation; Metabolism; Vertebrata; Chronic; Mammalia; Animal; Rheumatoid arthritis; Atorvastatin; Hydroxymethylglutaryl-CoA reductase; liver metabolism; Oxidoreductases; Pharmacokinetics; ezetimibe + simvastatin combination; Antilipemic agent

In this study, simvastatin, atorvastatin, ezetimibe, and ezetimibe + simvastatin combination were administered to arthritic rats, first to determine their effects on the inflammatory response, employing a low‐dose adjuvant‐induced arthritis model in rats. Arthritis was induced by the subcutaneous in...