Effects of dynamic cardiomyoplasty on indices of left ventricular systolic and diastolic function in a canine model of chronic heart failure

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 103; no. 6; pp. 1207 - 1213
• Main Authors: Cheng, Wang, Justicz, Alexander G., Soberman, Mark S., Alazraki, Naomi P., Santamore, William P., Sink, James D.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.06.1992; AATS/WTSA; Elsevier
• Subjects: Animals; Biological and medical sciences; Cardiac Surgical Procedures - methods; Cardiology. Vascular system; Chronic Disease; Diastole - physiology; Disease Models, Animal; Dogs; Electrodes, Implanted; Female; Heart; Heart Failure - chemically induced; Heart Failure - diagnostic imaging; Heart Failure - physiopathology; Heart Failure - therapy; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hemodynamics - physiology; Male; Medical sciences; Pacemaker, Artificial; Radionuclide Imaging; Surgical Flaps - methods; Suture Techniques; Systole - physiology; Ventricular Function, Left - physiology; Heart failure; Fissipedia; Animal model; Carnivora; Diastole; Cardiovascular disease; Plastic surgery; Systole; Plasty; Vertebrata; Chronic; Mammalia; Treatment; Animal; Heart disease; Myocardium; Left ventricle performance; Flap (surgery); Dog
• DOI: 10.1016/S0022-5223(19)34889-5
• ISSN: 0022-5223

The effects of cardiomyoplasty were evaluated with multiple-gated equilibrium radionuclide angiocardiography and catheterization in a canine model of chronic heart failure. Doxorubicin was administered to 12 dogs at a dose of 1 mg/kg/wk intravenously for 10 weeks. Left ventricular ejection fraction was reduced from a mean of 53.6% ± 3.4% to 33.5% ± 2.3% preoperatively. Two dogs died of presumed arrhythmia during this period. Cardiomyoplasty with the left latissimus dorsi muscle was performed on 10 dogs. The muscle was wrapped around both the left and right ventricles. Five dogs died of infection or arrhythmia after the operation. Postoperatively the muscle remained unstimulated for 2 weeks to allow adhesion to the heart. After this period, the latissimus dorsi muscle was conditioned by a progressive stimulation protocol. After the muscle was conditioned, multiple-gated equilibrium radionuclide angiocardiography studies showed that left ventricular global ejection fraction was 18.4% ± 7.2% at 0 volts (nonstimulation), 26.2% ± 3.7% at 5-volt stimulation (p < 0.05), and 31.0% ± 5.4% at 10-volt stimulation (p < 0.05). Regional ejection fractions in low lateral, apical, and low septal regions at 5 volts and 10 volts were higher than those at 0 volts (p < 0.05). Regional wall motion (percent radial shortening) of the low lateral region was higher than that during nonstimulation (p < 0.05). Peak emptying rate was 2.07 ± 0.95 end-diastolic counts per second at 0-volt, 3.10 ± 0.67 at 5-volt, and 3.34 ± 0.89 at 10-volt stimulation (p < 0.05). Peak filling rate was 1.81 ± 0.52 end-diastolic counts per second at 0-volt, 2.67 ± 1.18 at 5-volt, and 3.11 ± 0.65 at 10-volt stimulation (p < 0.05). Cardiac catheterization data showed a nonsignificant increase in left ventricular rate of pressure rise with increasing voltage (1302 ± 355 mm Hg/sec at 0 volts, 1450 ± 413 mm Hg/sec at 5 volts, and 1568 ± 455 mm Hg/sec at 10 volts). Left ventricular systolic pressures were unchanged. End-diastolic pressures decreased (11.2 ± 1.48 mm Hg at 0 volts, 10.4 ± 2.30 mm Hg at 5 volts, and 9.6 ± 1.52 at 10 volts; p < 0.05). These data show that cardiomyoplasty can improve indices of systolic and diastolic function in a canine model of chronic heart failure. (J Thorac Cardiovasc Surg 1992;103:1207-13)