Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: role of Akt and endothelial nitric oxide synthase phosphorylation

• Published in: Critical care medicine Vol. 36; no. 5; p. 1551
• Main Authors: Li, Jia, Zhang, Haifeng, Wu, Feng, Nan, Ying, Ma, Heng, Guo, Wenyi, Wang, Haichang, Ren, Jun, Das, Undurti N, Gao, Feng
• Format: Journal Article
• Language: English
• Published: United States 01.05.2008
• Subjects: Animals; Insulin - pharmacology; Male; Nitric Oxide Synthase Type III - metabolism; Oncogene Protein v-akt - metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - physiology

Intensive insulin therapy with tight glucose control is known to result in reduced morbidity and mortality in inflammation-related critical illness. Tumor necrosis factor (TNF)-alpha induction in myocardial infarction may trigger inflammation and have detrimental effects on cardiomyocytes. This stud...